Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functioning-FAP-photoenzyme-deciphered.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT Microalgae: the FAP enzyme on the road to biofuels https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/microalgae-FAP-road-biofuels.aspx ​In 2017, researchers from the CEA-BIAM and the CEA-Joliot discovered an enzyme with a rare property: when activated by light, it enables microalgae to convert their fatty acids directly into hydrocarbons. Today, together with the Institut Polytechnique de Paris, they have succeeded in understanding and demonstrating that this "FAP" enzyme can enable the production of fuel-like hydrocarbons thanks to an autocatalytic effect. Energies ; Biofuel ; Microalgae Researchers ; Teachers ; general public ; Journalists BIAM Scientific result électrochimie;catalyse; Fri, 31 Mar 2023 10:00:00 GMT Oxygen photoactivation for bio-inspired hydrocarbon catalysis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/O2-photoactivation-bio-inspired-hydrocarbon-catalysis.aspx The oxidative functionalization of alkenes, hydrocarbons widely used in the chemical industry, remains a challenge. A team from I2BC used an Oxygen Atom Transfer reaction to an alkene and succeeded in capturing the intermediate species of a bio-inspired photocatalyst produced during the reaction. Bio-inspired catalysis ; Green Chemistry SB2SM Scientific result Wed, 22 Feb 2023 11:00:00 GMT Exploring the potential of a model cyanobacterium for the photosynthetic production of high-value terpenes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Model-cyanobacterium-production-high-value-terpenes.aspx Through two publications, an I2BC team demonstrates the high biotechnological potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of high value-added organic compounds, the terpenes. Photosynthesis ; Microalgae ; Biotechnology SB2SM Scientific result Fri, 10 Feb 2023 11:00:00 GMT A small RNA regulates photoprotection in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Small-RNA-regulates-photoprotection-cyanobacteria.aspx A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA. Photosynthesis ; Microalgae ; Molecular mechanisms Scientific result Wed, 23 Jun 2021 10:00:00 GMT Green chemistry and biofuel: the functioning of a key photoenzyme deciphered https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functioning-FAP-photoenzyme-deciphered.aspx An international consortium of scientists, including an I2BC team, has just deciphered the functioning of FAP (Fatty Acid Photodecarboxylase), a key photoenzyme for the production of biofuels and other high value added molecules. This work, published in Science, was the object of a CEA press release. Green Chemistry ; Microalgae ; Biofuel Scientific result Mon, 12 Apr 2021 10:00:00 GMT Valorization of CO2 by bio-inspired catalysts: essential role of through-space electrostatic interactions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/CO2-valorization-ChemSusChem.aspx By studying the structure-reactivity relationships of bio-inspired catalysts for CO2 reduction, researchers from I2BC (SB2SM) and ICMMO have shown that the effects of through-space electrostatic interactions surpass the through-bonds electronic effects. A further step towards obtaining a durable catalyst to reduce the atmospheric accumulation of CO2, responsible for global warming. Green Chemistry ; Bio-inspired catalysis ; Carbon cycle Scientific result Wed, 24 Mar 2021 11:00:00 GMT Cyanothece PCC 7425, a new model cyanobacterium for the sustainable production of molecules of interest https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Cyanothece-PCC7425-new-model-cyanobacterium-limonene.aspx I2BC and SCBM teams have identified and reprogrammed a new model of cyanobacterium, Cyanothece PCC 7425, for the photosynthetic production of a high value-added monoterpene, limonene, used in many industrial applications. Photosynthesis ; Microalgae Scientific result Tue, 17 Nov 2020 11:00:00 GMT Methylglyoxal detoxification revisited in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Methylglyoxal-detoxification-in-cyanobacteria.aspx A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution. Photosynthesis ; Toxicology ; Microalgae News Fri, 04 Sep 2020 10:00:00 GMT Carbon-14 labelling of anti-inflammatory drugs with CO2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/C14-anti-inflammatory-drugs.aspx Researchers from the SCBM in collaboration with teams from IRAMIS, AstraZeneca and the Karolinska Institutet have developed a second marking method based on the dynamic exchange of carbon dioxide, this time without catalysis, by "simple" thermal heating. Ideal for organic molecules of therapeutic interest, the method is described in tAngewandte Chemie. Green Chemistry SCBM Scientific result isotopic exchange;radiolabeling; Mon, 04 May 2020 10:00:00 GMT Valorisation of carbon dioxide for the labeling of pharmaceutical compounds https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/valorisation-carbon-dioxide.aspx ​In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest. Green Chemistry ; Photosynthesis Scientific result Thu, 06 Sep 2018 10:00:00 GMT Phytoplankton needs allies https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Phytoplankton_needs_allies.aspx As part of an international collaboration, researchers from LI2D (SPI / Marcoule) and University of Warwick have highlighted the long-term benefits of the association between different marine microorganisms. The study published in Nature Microbiology shows that, contrary to what was admitted up to now, these microorganisms are in equilibrium and not in competition for micronutrients, because they form a complementary ecosystem. Microalgae ; Environment ; Health & life sciences Scientific result Fri, 30 Jun 2017 10:00:00 GMT