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The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation.
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Press release | Scientific publications | Scientific result | Bacteria | Antibiotics
Researchers from CEA, CNRS, Aix-Marseille Université and INRA, in France have discovered a unique system of acquisition of essential metals in the pathogenic bacterium Staphylococcus aureus. It represents a new potential target for the design of antibiotics. These results are being published in the journal Science on May the 27th 2016.
The so-called biologic metals are necessary for life. Pathogenic bacteria have developed elaborate systems to compensate for the low concentration of these essential metals in their environment, in particular within a host. The case of iron is particularly well documented with, in some bacteria, the production of molecules called siderophores that specifically capture iron in the medium. Researchers have now identified a new metal scavenging molecule produced in the bacterium Staphylococcus aureus and baptized it staphylopine.
Ghssein, G., Brutesco, C., Ouerdane, L., Fojcik C., Izaute, A., Wang, S., Hajjar, C., Lobinski, R., Lemaire, D., Richaud, P., Voulhoux, R., Espaillat, A., Cava, F., Pignol, D., Borezée-Durant, E. & Arnoux, P. (2016) Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science, 26 Mai 2016.DOI: 10.1126/science.aaf1018
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.