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Creation of hybrid complexes made from a protein and an inorganic complex - Application to oxidation catalysis


​Master in Chemistry - Master 1 Internship’s subject
Published on 14 September 2017


Laboratory: Chemistry and Biology of Metals laboratory
Head: Dr. Stéphane Ménage
Name of the team: Bioinorganic Chemistry and Environment (BioCE)
Head of the team: Dr. Stéphane Ménage
Name and quality of the internship’s head: Dr. Caroline Marchi-Delapierre, MCF, HDR
Address: Bâtiment K’, 17 avenue des martyrs, 38054 Grenoble cedex 9
Phone: 04 38 78 91 04

Creation of hybrid complexes made of protein and inorganic complex - Application to oxidation catalysis

Main goals:
The aim of this research theme is to optimize catalysts combining the advantages of chemical catalysis (great variety of reactions and substrates) with those of biocatalysis (high chemo- and enantioselectivity); the inorganic complex directing the reactivity while the protein serves as an asymmetric ligand, transferring the chirality to the substrate. Thanks to a close collaboration with the BioCat team from our Laboratory, our team is able to benefit from means such as crystallography of proteins to optimize the hybrid catalysts that it produces. This allows us to direct the synthesis of ligands as substrates in order to try to increase both the stability of the systems and their activity (reactivity and enantioselectivity). It is in this context that the student of M1 will be involved, i.e. he will have catalysts already developed in the laboratory and will benefit from the feedback on experience of our first experimental results in order to develop its own system (ligand and complex synthesis and catalytic application). The current developments of our research concern the use of molecular oxygen as oxidant, and CLEC technology for the heterogenization of the system.


Approaches & material used:
Organic multi-stage synthesis – (Biochemistry) - Catalysis – RMN - UV spectroscopy – HPLC - GC-MS - chiral GC.

Technical skills needed:
Organic synthesis – Inorganic synthesis – spectroscopy, reactivity study

Internship’s date:
In order to meet the deadline for entry to the CEA (3 months for the SPAS), the candidate must present himself as soon as possible.

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