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Needle and vaccine


​​​Human pathogenic bacteria such as Yersinia pestis and Pseudomonas aeruginosa, inject their toxins using a macromolecular nano-machine, the type III secretion system. Researchers at our institute recently discovered in P. aeruginosa that it was possible to use antibodies directed against the translocation pore of this secretion system in order to inhibit it. In this article these researchers show firstly that the constitutive protein of the translocation pore assembles itself into oligomers takinf the form of rings. The authors define on the other hand, at the molecular level, the region of the protein involved in bacterial toxicity. These findings will help to better target future developments of new vaccines or anti-microbial agents.​

Published on 10 October 2008

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