Highlight | Infectious diseases
Researchers at the Cell & Plant Physiology laboratory of our institute, at the laboratory adaptation and pathogenicity of microorganisms (University of Grenoble) and at the Laboratory of Microbial Ecology of the Rhizosphere and Extreme Environments (CEA/Cadarache) have shown that a molecule called FR235222, is able to specifically suppress the activity of an enzyme produced by parasites of animal cells, such as those that cause malaria and toxoplasmosis.
Bougdour et al
Drug-inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.
Journal of Experimental Medicine, 2009
Sautel et al
The histone methylase KMTox interacts with the redox-sensor peroxiredoxin-1 and targets genes involved in Toxoplasma gondii antioxidant defences.
Molecular Microbiology, 2009
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.