Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Scientific result | Chemistry | Pharmacology | Medical imaging
Deux équipes de l’Institut Frédéric-Joliot et leurs partenaires ont découvert une réaction chimique permettant de lier ou couper des molécules dans des milieux biologiques.
Chemists from the Institut des sciences du vivant Frédéric-Joliot have discovered that certain compounds, called iminosydnones, are able to rapidly react in biological environments with cyclic alkynes to form two new products: one from the binding of the two reaction partners, the other from a fragmentation of one of the two partners (Figure 1). They demonstrated that this reaction makes it possible to selectively label and purify a protein present in a very complex biological environment (e.g. liver extract).
How will "click and release" chemistry change the tools in the health sector? "There are many applications, mainly for therapy and imaging", replies Frédéric Taran, a researcher at the Institut des sciences du vivant Frédéric-Joliot, and the final author of the publication. "For example, targeted therapies involve binding a drug to an antibody that recognizes its target. It could be possible to inject a reagent to break the bond between the drug and the antibody once the target has been reached, so that the drug can have its effect. Work with the University of Strasbourg and the company Syndivia has demonstrated this functionality in blood samples." In imaging, this chemistry could be used to mitigate the drawbacks from the short life span of radioactive fluorine atoms commonly used in positron emission tomography (PET). Indeed, the association of an antibody with fluorine can take several days to reach its target, at which point the fluorine is no longer visible. The "click and release" solution would allow the radiotracer to be injected a few days after the injection of the antibody, and to bind the two at the desired moment.
Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes | Angewandte Chemie
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.