Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
According to an international study involving the LSCE, a reversal in the trend of terrestrial wind potential was observed in 2010. Its correlation with well-identified climatic mechanisms suggests the potential to optimize wind generation throughout the lifetime of facilities.
A NeuroSpin team, in collaboration with researchers from SHFJ and MIRCen (CEA-Jacob), is identifying a predictive indicator of the potentially deleterious effect of devices using ultrasound to deliver drugs to the brain.
A team from CEA-Joliot in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.
The Captot heavy metal sensor, developed by the Iramis-LSI over the last ten years, could be used to detect traces of uranium in water. This would be a simple, rapid field solution to monitor the environment, for example during the cleanup and dismantling of nuclear facilities.
Researchers at CEA-IRIG have used NMR to reveal the molecular mechanisms that support the adaptation of avian influenza virus from birds to humans. By uncovering the secrets of the interactions between the mutated viral polymerase and a key transcription factor in host cells, this new insight will make it possible to study the mechanism of cross-species contagion of these viruses and thus open up potential new therapeutic avenues.
A study on the effects of hydroxychloroquine in macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been published on Nature; the 22th oh july. Scientists from the CEA, CNRS, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing.
CEA-Joliot researchers and their partners have used a large-scale approach to map and characterize the response of CD4 T cells from healthy donors to two proteins of the Ebola-Zaire virus. They suggest that one of these proteins could be a target in the design of new vaccines.
Researchers at the CEA-Joliot (I2BC) have used NMR to decipher a novel mechanism in breast cancers linked to the BRCA2 gene.
The CEA-Irig (IBS) has reported in Nature Catalysis a review on SAM proteins, a type of catalyst that produces highly reactive radical species.
To be or not to be expressed? Researchers at the CEA-Irig (IBS) are showing with precision how a bacterial metalloprotein controls the expression of certain genes. And all it takes is an electron and a proton!
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.