Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
A team from CEA-Joliot in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.
Researchers at the CEA-Iramis and their partners have locally grafted organic molecules onto gold nanoparticles, using two photopolymerization steps. This new flexible functionalization technique can be used for applications ranging from biosensing to photonics.
According to an international collaboration involving the LSCE (CEA-CNRS-UVSQ), the doubling of atmospheric CO2 content compared to the pre-industrial era would “probably” warm the earth between 2.6°C to 3.9°C. This assessment – the best to date – is based on three independent data sources that do not use climate models.
Researchers at CEA-IRIG have used NMR to reveal the molecular mechanisms that support the adaptation of avian influenza virus from birds to humans. By uncovering the secrets of the interactions between the mutated viral polymerase and a key transcription factor in host cells, this new insight will make it possible to study the mechanism of cross-species contagion of these viruses and thus open up potential new therapeutic avenues.
A study on the effects of hydroxychloroquine in macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been published on Nature; the 22th oh july. Scientists from the CEA, CNRS, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing.
An international consortium of scientists, including the Laboratoire des Sciences du Climat et de l'Environnement (LSCE - CEA/CNRS/UVSQ, Institut Pierre Simon Laplace, Université Paris-Saclay), used a new method to refine the map of caesium and plutonium radionuclide concentrations in soils in France and several neighbouring countries.
CEA-Joliot researchers and their partners have used a large-scale approach to map and characterize the response of CD4 T cells from healthy donors to two proteins of the Ebola-Zaire virus. They suggest that one of these proteins could be a target in the design of new vaccines.
Chemists at Iramis have proposed a new pathway for the catalytic synthesis of methanol from a formic acid derivative – a waste product of the silicon industry – whose by-products can be recycled. This is a high-yield, sustainable and environmentally friendly process that can be used for energy storage and fine chemistry!
With virtually zero background noise, the CUPID-Mo experiment at the Modane Underground Laboratory, in which the CEA-Irfu is participating, is setting a new non-detection limit for the hypothetical “neutrinoless double beta decay” (0νββ), which has never been observed. If it occurred, this detection would prove that neutrinos are their own antiparticles and would explain the predominance of matter over antimatter in the Universe.
Researchers at the CEA-Joliot (I2BC) have used NMR to decipher a novel mechanism in breast cancers linked to the BRCA2 gene.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.