Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Scientific result | MRI | Diagnosis
Noting that the elastic properties of tissues is closely linked to their microscopic structure (cell density, presence of fibers), the researchers tested the hypothesis that tissue elasticity can be directly estimated from images captured using diffusion MRI, i.e. based on the diffusion of water molecules rather than using mechanical vibrations. Developed in 1985 by Denis Le Bihan and his collaborators at the Frédéric-Joliot Life Sciences Institute, diffusion MRI (dMRI) is now widely used in medical imaging. This technique is very sensitive to tissue structure at the microscopic level.
The degree of liver fibrosis estimated through MRE and dMRI are 100% concomitant. This work has also pointed to a new type of contrast that can be produced from the elasticity images obtained by diffusion MRI. By simulating the passage of shear waves of any frequency or amplitude in the tissues, and without the technical difficulties of MRE, tissue structure heterogeneity can be revealed—in tumors in particular.
This result was the subject of a press release and a patent application by CEA.
Diffusion and Intravoxel Incoherent Motion MR Imaging-based Virtual Elastography: A Hypothesis-generating Study in the Liver | Radiology
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.