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Agenda


Séminaire conjoint des jeunes chercheurs de l’IBS et du PSB

RNA polymerases : transcription and beyond

​​​​​​27/11/​2026 @ 11:00​ Salle de séminaire IBS, 71 avenue des Martyrs, Grenoble

Publié le 27 novembre 2026
Pr Carlos Fernandez Tornero
Biological Research Center | CSIC
​Madrid, Espagne
RNA polymerases are large macromolecular assemblies that transcribe the genome in all organisms. Because RNA polymerases work on the chromatin, their activity is connected to other cellular processes such as DNA repair and DNA integration. Eukaryotic RNA polymerases I and III (Pol I and Pol III) synthesize untranslated RNAs that mediate protein synthesis, regulate gene activity or catalyze chemical reactions. In the talk, Carlos Fernández-Tornero will present results on the roles of yeast Pol I and Pol III in transcription, DNA lesion detection and retrotransposon integration. Pol I transcription is regulated through enzyme hibernation (Torreira et al., eLife 2017), a mechanism that was later shown to operate in other RNA polymerases. Besides, detection of DNA lesions by Pol I depends on its intrinsic RNA cleavage activity and differs from other RNA polymerases (Sanz-Murillo et al., PNAS 2018 ; Santos-Aledo et al., Nat Commun 2025). Finally, Pol III mediates integration of yeast retrotransposon Ty1 upstream of transfer RNA genes, a mechanism that ensures insertion at safe genome locations (Nguyen et al., Nat Commun 2023 ; Huecas et al., unpublished). Altogether, these results underscore the prominent role of RNA polymerases in chromatin-associated cellular processes​.​
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