Pr David Skurnik
Département de microbiologie clinique, Hôpital Necker- Enfants Malades, Université Paris Cité, Paris
High-throughput sequencing and particularly original applications such as the TnSeq allow a study of host-pathogen interaction at the full genome scale through a systematic analysis off all the virulence factors of a bacteria in a particular setting. For example, all the genes important or essential for GI tract colonization of the selected pathogenic bacteria.
This allows to reveal new targets for vaccine development. Interestingly, an ongoing adaptation of the TnSeq allows the systematic identification of these antigens of interest. We call this new technology : TnVaccine.