We are looking for a highly motivated research engineer / post doctorate researcher to join our innovative research program on skin tissue engineering and regenerative medicine, as part of the Bioengineered Skin-France initiative. This project aims to develop next-generation skin substitutes with enhanced immunotolerance, vascularization, and regenerative potential. The successful candidate will work at the intersection of advanced skin models, organoid technologies, and molecular engineering, contributing to translational research with direct preclinical and clinical applications.

Key Responsibilities

• Develop and optimize skin organoid models, integrating keratinocytes, fibroblasts, and endothelial cells.
• Perform cell culture and maintain skin cell lines under chemically defined conditions.
• Apply CRISPR/Cas9 genome editing to engineer cells with immunomodulatory properties
• Conduct molecular and cellular biology experiments (e.g., sequencing, immunophenotyping, transcriptomic analysis).
• Collaborate on preclinical animal models (mouse and porcine xenografts) to evaluate graft functionality.
• Ensure compliance with GMP guidelines for bioengineered skin products.
  

Qualifications

• Ph.D. in Cell Biology, Biotechnology, Molecular Biology, or a related field.
• Hands-on experience in skin cell culture.
• Expertise in keratinocytes and fibroblasts handling or organoid models or 3D tissue engineering is a strong advantage.
• Proficiency in molecular biology techniques and advantageously on CRISPR/Cas9 gene editing.
• Familiarity with sequencing technologies and data interpretation.
• Certification to work with animal models in preclinical research will be positively considered.

Transversal Competences

• Strong organizational and communication skills to collaborate in a multidisciplinary environment.
• Maintaining a comprehensive lab notebook and ensuring data traceability.
• Adhering to health & safety regulations and laboratory protocols.
• Ability to present, share, and discuss research findings with internal and external collaborators.

Application Requirements

Interested candidates should submit the following documents:

1. A cover letter detailing research interests and relevant experience.
2. A curriculum vitae (CV) including a list of publications.
3. Contact information for three references.

This 18 month position offers an exciting opportunity to contribute to groundbreaking research at the interface of biotechnology, regenerative medicine, and translational skin research.

We look forward to receiving your application!