Context: Following the European Green Deal and France's anti-waste law, the new EU Regulation on
Packaging and Packaging Waste sets ambitious recycling targets, introducing stringent standards for
packaging recyclability and establishing categories for contact-sensitive plastic packaging intended for
children. It mandates recycling 65% of packaging waste, including 50% of plastics, by 2025. Despite
the advancement, this represents a great challenge and requires development of robust methods for
authenticating the origins, processing histories, and decontamination levels of recycled materials.
Objective: This PhD project is a part of an ambitious collaborative project TWINLOOP (funded by
AMI from ANR in 2025). The objective of this PhD is to develop and integrate state-of-the-art
technologies, such as electronic noses (eNs), to enhance the safety and efficiency of recycling
processes for plastics in food contact applications. At SyMMES lab, we have developed biomimetic
eNs based on biological sensing materials such as peptides and an optical detection system, surface
plasmon resonance imaging (SPRi) 1-5. Our eN has demonstrated excellent performances in terms of
sensitivity and selectivity. In addition, our technology has been valorized by the creation of a company
for the development of portable device for artificial olfaction. In this project, in close collaboration
with this company, the electronic nose will be applied for the analysis of recycled plastic materials to
detect chemical contamination across various recycling stages. Novel peptides with higher selectivity
for target volatile organic compounds will be designed based on virtual screening approach to further
improve the performances of the eNs. Besides, strategies for adapted gas sampling and preconcentration
will be explored and integrated into the electronic nose system with the aim of
optimizing and testing inline applications of eNs. Finally, the project includes also the development of
data treatment based on machine learning.
Background of candidates: We are seeking a highly motivated researcher who has recently
completed a master’s degree in physics, chemical physics, or chemical engineering with strong
interest on the biology and nanotechnology. Experience with numerical simulations and AI are
highly appreciated. This PhD candidate will be based at CEA-Grenoble and will start ideally on
September/October 2025.
References:
(1) S. Brenet, et al., Y. Hou*, “Highly-Selective Optoelectronic Nose Based on Surface Plasmon Resonance
Imaging for Sensing Volatile Organic Compounds”, Analytical Chemistry, 2018, 90 (16), 9879.
(2) S. Gaggiotti, et al., Y. Hou*, D. Compagnone*, “Development of an optoelectronic nose based on surface
plasmon resonance imaging with peptide and hairpin DNA for sensing volatile organic compounds”, Sensors
and Actuators: B. Chemical, 2020, 303, 127188.
(3) S. Brenet, et al., Y. Hou*, “Improvement of Sensitivity of Surface Plasmon Resonance Imaging for the Gas-
Phase Detection of Volatile Organic Compounds”, Talanta, 2020, 212, 120777.
(4) J. S. Weerakkody, et al., Yanxia Hou, * “A Surfactant-like Peptide Self-assembled into a Biohybrid Multisensor
Array for an Electronic Nose”, ACS Nano, 2022, 16, 3, 4444.
(5) M. El Kazzy, et al., Y. Hou,* “Study and Optimization of the Selectivity of an Odorant Binding Proteinbased
Bioelectronic Nose”, Biosensors and Bioelectronics, 2025, 268, 116879.
For application, please send your CV, letter of motivation, and bachelor/master transcripts
before to: Dr. Yanxia HOU-BROUTIN, Dr. Arnaud BUHOT
Email: yanxia.hou-broutin@cea.fr; arnaud.buhot@cea.fr Tel: 04 38 78 94 78
Laboratory: Molecular Systems and Nanomaterials for Energy and Health (SyMMES
UMR5819 CEA-CNRS-UGA-Grenoble INP), 17 Avenue des Martyrs, 38054 Grenoble
Website: https://www.symmes.fr/en/Yanxia-Hou/Pages/CV.aspx