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In 2016, 3,133,000 people were treated for chronic respiratory diseases (CKD), excluding cystic fibrosis. CKDs are characterized by an increase in the permeability of bronchial lumen to antigens and pro-inflammatory molecules. Understanding the pathophysiological causes of the deregulation of this permeability should lead to the development of new therapeutic approaches.
Bronchial epithelial cells play a central role in maintaining a tight and selective physical barrier by setting up structures called "junction complexes" (JC; see figure), located between the cells. This barrier protects the respiratory tract against pollutants, allergens, fine particles and microorganisms. In infectious and inflammatory pneumopathies such as cystic fibrosis, excessive permeability of this pulmonary epithelium is observed. The molecular mechanisms underlying the increased permeability are poorly understood and deserved to be investigated.
During their study of the mechanisms involved in maintaining JC, researchers at the Irig identified normal cellular prion protein (PrPC) as essential protein that control JC homeostasis. They demonstrated that, in addition to its interaction with JC proteins, PrPC contributes to the maintenance of the epithelial barrier by protecting JC proteins from degradation induced by inflammation and copper associated oxidative stress.
These results provide new insight into the role of PrPC in the pulmonary barrier defense. Hence, PrPC protein should be ranked among proteins involved in the protection of the lung barrier in infectious and inflammatory pneumopathies.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.