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Highlight | Simulation ＆ modelling
Researchers at IRIG have simulated the role of laccase, an enzyme for processing aflatoxins, which are a major food safety concern. Experimental and theoretical approaches were combined to evaluate the ability of this enzyme to detoxify these mycotoxins.
Aflatoxins are known to be highly toxic, as they can have serious health consequences for humans and animals. They are toxic fungal metabolites that can contaminate a wide range of food and feed crops, including peanuts, corn and tree nuts. They are produced by certain species of Aspergillus fungi, which grow on crops before or after harvest, especially under warm, humid conditions. Exposure to aflatoxins has been associated with an increased risk of various cancers, including lung and digestive cancers.
The results of this study suggest that laccase may be a promising enzyme for the detoxification of aflatoxins. Further research will be needed to explore potential applications and deploy laccase-based detoxification strategies in the food industry.
Zaccaria M, Dawson W, Russel Kish D, Reverberi M, Bonaccorsi di Patti CM, Domin M, Cristiglio V, Chan B, Dellafiora L, Gabel F, Nakajima T, Genovese L & Momeni BExperimental-theoretical study of laccase as a detoxifier of aflatoxins Scientifc Report 2023
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.