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Highlight | Cancer
Basic research and pre-clinical research are carried out together to better understand the mechanisms of cancer development and to propose more effective treatments. For example, researchers at IRIG are interested in the behavior of the NLRP7 protein that contributes to the growth and tumorigenesis of placental cancer, known as gestational choriocarcinoma. These results targeting the NLRP7 protein open the way to new therapies.
Placental cancer, or gestational choriocarcinoma, can unfortunately cause maternal death even several years after the pregnancy. Researchers at IRIG are studying the behavior of the NLRP7 protein involved in inflammatory processes suspected in the development of this cancer. In 2021, they had shown that the overexpression of NLRP7 in placental cancer cells contributed to their metastasis to other organs, such as the liver, the lung or the brain.
Reynaud D, Alfaidy N, Collet C, Lemaitre N, Frederic Sergent F, Miege C, Soleilhac E, Al Assi A, Murthi P, Courtois G, Fauvarque MO, Slim R, Benharouga M and Abi Nahed RNLRP7 enhances choriocarcinoma cell survival and camouflage in an inflammasome independent pathwayCells 2023
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.