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For personalized medicine, it is essential to identify cancer patients who are most at risk in order to offer them appropriate treatment. Researchers at IRIG have demonstrated the prognostic potential of type VII collagen expression using data from kidney tumor samples.
Sometimes diagnosed at an advanced stage, cancer can progress, spread to distant organs (metastasis) and/or reappear after treatment. Assessing patients' chances of survival would therefore help clinicians to improve disease management. Researchers at IRIG investigated the prognostic potential of each gene to identify new biomarkers for predicting patient survival in clear cell renal cell carcinoma, the seventh most common type of cancer in the Western world. Their research revealed that increased expression of the
COL7A1 gene, encoding a specific form of collagen, correlates with the advancement of this cancer and therefore with the risk of death (Figure A). Moreover, this high expression also makes it possible to identifiy patients most at risk among patients of the same stage, such as stage II (generally with a good prognosis) (Figure B). This new method of survival assessment is complementary to, and more precise than some of the methods (such as the stage) used today in the clinic. Since the COL7A1 biomarker is robust, it can be applied to patients of different genetic/ethnic origins or who have undergone different therapies.
Koca D, Séraudie I, Jardillier R, Cochet C, Filhol O and Guyon L. COL7A1 expression improves prognosis prediction for patients with clear cell renal cell carcinoma atop of stage.Cancers 2023
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.