Our institute is composed of 5 departments
Laboratories of the Institute
Publications, Books & Publishing, Defended theses
Autophagy is a recycling system of macromolecules that allows cells to survive critical situations such as nutrient deprivation and degradation of damaged organelles. This study demonstrates that many genes involved in autophagy are characterized by an increase in their expression variance without change in the average expression in tumors. This result sheds new light on this biological process whose overall effect on tumor progression and treatment response is contextual.
Gene expression is the process by which genetic information is translated into functional macromolecules. Transcription is the first step in this process, which involves the synthesis of messenger RNAs (mRNAs) from the corresponding gene DNA template. Over the past few decades, genome-wide transcriptional profiling approaches have made it possible to assess the expression levels of thousands of genes in parallel in various biological contexts. In statistical analyses, the expression of a gene is estimated by counting the number of occurrences of the corresponding mRNA sequences over a set of samples and is defined by two dimensions: the mean and the variance.
Le Priol C, Azencott C-A and Gidrol X
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.