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The last two years in scientific news
Find our latest scientific news, as well as coming and past seminars and PhD defences.
Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments.
As part of an international study published in The Journal of Biological Chemistry, a team from LMN (MIRCen/CEA-Jacob) discovered an unexpected mechanism involving chaperone proteins in Tau disassembly.
At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases.
A study on preclinical imaging involving several national research organisms (Inserm, CNRS, CEA, Universities) has produced MRI relaxometry maps for healthy rat brains. The impetus for that work is to be found in the France Life Imaging (FLI) initiative and its continuing momentum manifests today as the Small Animal Imaging Network (SAIN), which unites about ten French imaging facilities. The study, published in Frontiers in Neuroinformatics, demonstrates the feasibility of large-scale, multicenter, MRI studies in the preclinical setting.
The term "synucleinopathy" covers a range of diseases, including Parkinson's disease, Lewy body dementia and multiple system atrophy, that involve pathological alpha-synuclein aggregations. An analysis of the properties of the different aggregate strains present in synucleinopathies has delineated the molecular bases of the diseases. The study, led by MIRCen (CEA-Jacob) researchers in partnership with the University of Louvain and Imperial College London, was published in Acta Neuropathologica
The weekly MIRCen laboratory meeting is a particularly important time, at which external collaborators or students from the laboratory present their research projects.
Below is a list of speakers from external laboratories invited to speak at these meetings in the next few months.
If a PhD thesis is to be defended at the CEA at Fontenay-aux-Roses, it is possible to attend provided that a completed form is sent to the MIRCen secretary at least three days in advance.
Contact CEA ou Contact Inserm
PhD Student: Marianne Maugard.
Les patients atteints de la maladie d'Alzheimer ont des déficits du métabolisme cérébral du glucose une quinzaine d'années avant les premiers défauts cognitifs, suggérant que le métabolisme pourrait contribuer à la physiopathologie de la MA. Pour mieux comprendre les mécanismes qui relient le métabolisme énergétique et l'activité synaptique, nous nous sommes intéressés à la production de L-serine, une molécule dont la synthèse de novo dérive d'un intermédiaire de la glycolyse.
PhD Student: Séverine Maire.
Huntington’s disease (HD) is a genetic disorder caused by the expansion of a CAG repeat in the first exon of the Huntingtin gene (HTT). We propose to use trans-splicing to develop a gene therapy vector that will significantly reduce or eliminate the expression of the mutant protein while restoring a physiological level of normal HTT in cells affected by the HD mutation.
PhD Student: Jérémy Pépin.
Previous studies have shown that the metabolic profile measured in ¹H NMR spectroscopy can be altered in patients with Huntington's disease. Hypotheses involving defects in energy metabolism have been advanced to explain partially the pathophysiology of the disease. The metabolic actors could thus be biomarkers of interest. All of the results and methods implemented during this thesis show the potential of a promising MRI modality called CEST (Chemical Exchance Saturation Transfer) to identify potential biomarkers of neurodegenerative diseases.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.