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The last two years in scientific news
An international study involving IDMIT's (CEA-Jacob) Roger Le Grand and other researchers from more than 80 countries concluded that chloroquine and hydroxychloroquine likely provide no clinical benefits in the treatment of COVID-19.
In a study published in Scientific Reports, researchers from Genoscope (CEA-Jacob) showed that a same bacterium can degrade chlordecone differently according to the conditions in which it was cultured. Furthermore, one of the newly-identified transformation products was detected in chlordecone-contaminated mangroves in the French West Indies.
A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen.
Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols.
Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments.
A NeuroSpin team, in collaboration with researchers from SHFJ and MIRCen (CEA-Jacob), is identifying a predictive indicator of the potentially deleterious effect of devices using ultrasound to deliver drugs to the brain.
IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics.
At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases.
Paris-Saclay University as well as its component institutions and member-associated universities , their partner national research organisms, and the LERMIT, CHARMMMAT, LASIPS and NanoSaclay laboratories of excellence (LabExs) collectively decided to release funds for research projects targeting the COVID-19 pandemic. Among the laureates are the CNRGH and IRCM, with their respective projects COVIDOGEN and BIOTHETARCOVI.
As a part of the Covid-19 Flash call launched on March 6, 2020, the ANR selected 86 research projects for immediate funding, covering a large number of issues related to the Covid-19 epidemic. Among the selected projects, one project coordinated by Roger Le Grand (IDMIT) focuses on the study of the pathogenesis of the SARS-Cov-2 infection in a pre-clinical study model.
The FRM has just selected eight research projects in its call for projects on the fundamental mechanisms of Alzheimer's disease. A financial contribution of up to 600,000 euros has been allocated to fund the salaries, equipment and operating costs for each project for a period of 2 to 3 years. Among the funded projects, a project led by SEPIA (CEA-Jacob), Genoscope (CEA-Jacob) and ENS-Saclay, focuses on the use of cerebral organoids or 'mini-brains' as a model for the study of Alzheimer's disease.
The French Plan for Neurodegenerative Diseases 2014–2019 (PMND; Plan maladies neuro-dégénératives) has been completed. The French National Research Agency and ITMO Neurosciences, Cognitive Sciences, Neurology, Psychiatry are holding a day-long colloquium to review the projects that received funding in the field between 2011 and 2014. The colloquiumn an online event, is open to the totality of the scientific community after mandatory pre-registration.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.