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The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
In an article published in Environmental Pollution, a consortium of researchers from a range of institutions (CEA-Jacob/Genoscope & LSCE, University of Évry–Paris-Saclay University, Inrae, IRD, BRGM, University of Strasbourg, University of Lorraine, University of Mayotte) questions recent findings on the persistence of chlordecone contamination in French West Indies soils.
In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis.
Working with a model poplar line, researchers from the University of Orléans, Inrae, the University of Lorraine and CEA-Jacob's CNRGH have shown that the tree's epigenetics controls the development of ectomycorrhizas, i.e., the symbiotic relationship between the roots of certain trees and soil fungi.
In a clinical trial, the IMVA-HB/IDMIT autoimmune team (UMR-S 1184 CEA/Inserm/UPSaclay/Kremlin Bicêtre Hospital) headed by Xavier Mariette has demonstrated the therapeutic benefits of the association of rituximab and belimumab for the treatment of Sjögren syndrome.
In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities.
In a work published in Environmental Pollution, researchers from iRCM's LDG laboratory explored the effects of exposure to two bisphenol A substitutes, BADGE and BPAF, on murine germ cells, and more specifically on oocytes and their precursors.
In a study published in Life Science Alliance, Genoscope researchers paired cell engineering and transcriptomics to explore gene regulatory programs driven by retinoic acid receptors and what role they play in neuronal differentiation.
In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.