The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
Under the coordination of the MSF Foundation, researchers and engineers from the University of Évry, the CEA, the CNRS, Médecins Sans Frontières and the Bacteriology/Virology Department of the Henri-Mondor hospital (AP-HP) teamed to develop a mobile application to ease the determination of antibiotic resistance.This application aimed at addressing a major public health issue will be freely available to medical personnel worldwide once clinically validated and CE certified. The demonstration of the technical feasibility of their approach was published on 19 February 2021 in Nature Communications.
In an article entitled "Reactive astrocyte nomenclature, definitions, and future directions," published as a first consensus statement in the journal Nature Neuroscience, more than 80 international specialists, including Carole Escartin from LMN (MIRCen/CEA-Jacob) as first co-author, have established a nomenclature and definitions for reactive astrocytes.
Genoscope was part of an international team that assembled the genome of Cotesia wasps and identified therein chromosomal colonization by a virus that settled into the wasp genome a hundred-million years ago. Their results suggest that the evolutionary course of a virus integrated within the genome of a eukaryote changes completely when the former is beneficial to the latter.
Researchers from LABGeM (CEA-Jacob), LaMME and the Pasteur Institute joined forces to develop a novel method for the analysis of prokaryote pangenomes, called PPanGGoLiN. As a complement to PPanGGoLiN, the team developed a second tool, panRGB, which brought unprecedented performance and speed to massive comparative genomics analyses.
A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues.
The CNRGH contributed to a work showing that tobacco exposure, even when stopped before becoming pregnant, leaves traces in the placenta in the form of epigenetic modifications to its DNA.
Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease.
In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.