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The François Jacob Institute of Biology brings together five departments and three services
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The CEA is recruiting a Head of Radiotoxicology Laboratory (on a permanent position (CDI), to work at the Bruyères-le-Châtel and Fontenay-aux-Roses sites. Within the DRF, our laboratory is part of the Department of Cellular and Molecular Radiobiology (DRCM), which is dedicated to research in radiobiology, radiotoxicology, DNA repair, genomic stability, tissue regeneration, and oncogenesis, through the use of cellular and preclinical models. The Radiotoxicology Laboratory (LRT) is a radioactive ICPE-classified unit that conducts research on actinides and other radionuclides, combining biology, physics, medicine, and pharmacy. In particular, it contributes to understanding the fate of radionuclides in the body and to the development of post-exposure treatments, in connection with NRBC issues and nuclear medicine.
Offer details
The CEA is recruiting a researcher on a permanent contract (CDI) in the Radiotoxicology Laboratory (LRT) at the Bruyères-le-Châtel and Fontenay-aux-Roses sites. Within the DRF, The LRT is part of the Department of Cellular and Molecular Radiobiology (DRCM), which is dedicated to research in radiobiology, radiotoxicology, DNA repair, genomic stability, tissue regeneration, and oncogenesis, through the use of cellular and preclinical models. The LRT is a radioactive ICPE-classified unit that conducts research on actinides and other radionuclides, combining biology, physics, medicine, and pharmacy. In particular, it contributes to understanding the fate of radionuclides in the body and to the development of post-exposure treatments, in connection with NRBC issues and nuclear medicine.
The position will be attached to the Stem Cells and Radiation Service (SCSR), which is one of the three services of the Department of Cellular and Molecular Radiobiology (DRCM, https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/IRCM/IRCM.aspx), which is part of the Francois Jacob Institute of Biology and the Fundamental Research Directorate of the CEA. Located in Fontenay-aux-Roses (10 km from Paris city centre), the DRCM (Department of Clinical Research and Management) dedicates its work to research in radiation biology, DNA repair, genomic stability, tissue regeneration, and oncogenesis, using cellular and preclinical models. The SCSR (Center for Scientific and Clinical Research) brings together laboratories working on the biology of several types of somatic (brain, blood, skin) and germline stem cells in humans and mice. The SCSR is interested in their tissue regeneration potential, their responses to ionizing radiation, and their permissiveness to cancerous transformation. The SCSR focuses these themes on cellular and molecular mechanistic aspects with the aim of translational applications within regional, national, and international clinical scientific networks. The recruited Researcher, a future Principal Investigator (PI) in Stem Cell Biology and Radiobiology, will work in the field of germ cells or hematopoietic cells and contribute to research with a strong fundamental and translational impact. They will develop cutting-edge projects primarily within the SCSR laboratories working on hematopoiesis (Team Niche, Cancer and Radiation in Hematopoiesis, PI: F Pflumio) or on germline differentiation (Team Germline Differentiation, PI: G Livera).
A fully funded PhD position is available in the team “Laboratoire de Radiobiologie Génétique et Moléculaire”, headed by Éric Coïc, at the JACOB institute, CEA, Fontenay-aux-Roses, FR. Our team focuses on elucidating the molecular mechanisms that govern homologous recombination (HR) in yeast (https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/IRCM/Equipes/LRGM.aspx ). HR is a major pathway for the accurate repair of DNA double-strand breaks and single-stranded DNA gaps, as well as for the restart of stalled or collapsed replication forks. A key step in HR is the formation of Rad51 nucleoprotein filaments on the single-stranded DNA generated by these breaks. We showed in yeast that a strict control of these filaments is essential to prevent HR from inducing chromosomal rearrangements. In humans, the functional homologs of the control proteins are tumor suppressors. Thus, the control of HR appears to be as important as the HR mechanism itself. Our project involves the use of newly developed molecular tools that will provide unprecedented insight into the mechanisms governing these regulatory pathways. Notably, we will employ a functional fluorescently tagged version of Rad51 protein first developed by our collaborators A. Taddei (Institut Curie), R. Guérois and F. Ochsenbein (I2BC, Joliot, CEA). This major advance will enable us to visualize the effects of regulatory proteins on DNA repair dynamics following various types of DNA damage using live-cell microscopy. We have also developed highly accurate structural models of control protein complexes in association with Rad51 filaments. We will use a multidisciplinary approach based on genetics, molecular biology, microscopy, biochemistry, protein structure and AI-designed peptide inhibitors to understand the function of Rad51 filament formation regulators.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.
