Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Plateforms, equipments and expertise
Researchers at the DSV develop methodologies and innovative skills to understand the dynamics and structure of macromolecules within the complexity of the cell.
The DSV has a structural biology platform in Grenoble – the Institut de biologie structurale (IBS) – and a biophysics platform in Saclay, within the CEA-IBITECS. The DSV teams involved in these platforms are endowed with a variety of equipment and numerous fields of expertise, especially in crystallography, NMR spectroscopy and optical spectroscopy. These teams also develop methodologies that make exploring the living more efficient. Both platforms are certified by IBiSA and participate in the national infrastructure in biology and health FRISBI.
The IBS directly benefits from its proximity to the ESRF synchrotron radiation source. In addition, it is a member of the Partnership for structural biology (PSB) along with the EMBL, ESRF and ILL. The IBS, driven by an innovative approach, has an internationally recognized expertise in producing/characterizing soluble proteins and membranes; determining their structure, folding and dynamics; and analyzing macromolecular complexes and interactions. A few examples:
Supervisor: Winfried WEISSENHORN
The biophysics platform at IBITECS arose from the mastery of a consistent body of spectroscopic methods for structural biology by several of its teams. It provides access to a wide range of optical and magnetic spectroscopies (absorption spectroscopy, electronic fluorescence, Raman, infrared, electron paramagnetic resonance (EPR), NMR, time-resolved spectroscopy, etc.) that are particularly used in radiobiology (i.e. to study the genomic integrity of the cell nucleus) and bioenergy (i.e. to study photosystems and especially hydrogenases). Supervisor: Bruno ROBERT
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.