Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Cellular mechanisms | Cognition | Molecular mechanisms
Researchers at the DSV are expanding the fundamental
knowledge of cellular architecture, organization, regulation, and their
interactions with the exterior environment. They also explore the
biochemical reactions regulating cell functions (e.g. energy production,
manufacture and transport of molecules, damage repair, and waste
elimination). All of this information helps to understand how certain
physiological processes shift from normal to pathological, in addition
to identifying novel therapeutic, diagnostic or methodological leads
This research forms the basis of the CEA’s
innovation in the fields of radiation biology, therapy and diagnosis.
The focus is on three areas:
Researchers at the DSV implement a multi-scale approach to study living organisms, using specific skills at their disposal:
Using almost fully automated processes, researchers at Irig have designed a three-dimensional microenvironment in which cells form a tissue resembling a mini-tumor. Their work opens new perspectives for personalized medicine.
Researchers at the Irig, in collaboration with the CEA-Leti, have developed a microfluidic chip that can measure insulin secretion from a single pancreatic islet. The same technology can be adapted to other biological tissues and secretomes.
At the CEA-Joliot’s NeuroSpin neuroimaging center, the Iseult project’s 11.7-tesla MRI produced its first images in September 2021, thanks to the extraordinary magnet developed by the CEA-Irfu. Read on for a look at the origins behind this world premiere.
With the help of a “bone marrow on a chip”, researchers at Irig and their partners (Inserm, Hôpital St-Louis, Paris Diderot University) have observed the onset of differentiation in stem cells, before their transformation into blood cells. Upon contact with a bone cell, some of them completely reorganize. This unexpected discovery opens up entirely new paths for the study of a number of diseases such as leukemia.
Researchers at the CEA-Jacob (Immuno-Hematology Research Unit – SRHI) have designated a new target for the immunotherapy treatment of clear cell renal cell carcinoma, aimed at patients who cannot undergo conventional immunotherapy.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.