Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Plateforms, equipments and expertise
Due to its strong positioning in all “omics” approaches, the DSV has mastered high throughput techniques allowing the simultaneous analysis of a large number of variables in genomics, transcriptomics, proteomics, metabolomics and lipidomics.
As one of the means for methodological innovation at the DSV, large-scale biology or “omics” (e.g. genomics, proteomics, metabolomics, and lipidomics) platforms are an asset to research conducted in the energy and health fields. Combined with the DSV’s expertise in biodiversity exploration, these platforms make it possible to propose biotechnology applications for bioenergy production and green chemistry. In the health field, they identify biomarkers for diagnostics or therapeutic monitoring (i.e. for use with cancer). These platforms generate massive amounts of data, whose analysis relies on the resources of the CEA’s computing research and technology center (CCRT), as well as the expertise of teams in the bioinformatics field.
The DSV’s sequencing and genotyping platforms (at the CEA-IG in Évry) represent the second largest sequencing capacity in Europe. This capacity is used equally well for analyzing normal and pathological genomes, as for identifying biomarkers and biological functions useful to industry or evolutionary studies. Among its various resources, MicroScope works to annotate microbial genomes and characterize the biological functions of their genes. Epigenetic studies, genome-wide association studies (GWAS) and even pangenomic expression studies are also performed, in order to provide information about the genes involved in the pathogenesis of human diseases. Certified by IBiSA, the IG platforms are the driving force behind France Génomique, a national infrastructure in biology and health. The IG coordinates the infrastructure.Supervisor: Pierre LE BER
The « Étude de la dynamique des protéomes » (EDyP) platform (at the CEA-IRTSV in Grenoble) has combined an expertise in the proteomics analysis of complex biological samples with the quantification of proteins by mass spectrometry. EDyP is an IBiSA platform (Grenoble Proteomics Infrastructure) and coordinates the national infrastructure in biology and health ProFi, of which it makes up one of three national sites.Supervisor: Christophe BRULEY
MetabolomeIDF (at the CEA-IBITECS in Saclay) provides expertise in atmospheric pressure ionization mass spectrometry (API-MS). This enables analyzing biological samples from medical cohorts in order to discover diagnostic biomarkers, in addition to disease monitoring. MetabolomeIDF is the Île-de-France site for MetaboHub, the national infrastructure in biology and health dedicated to characterizing biomarkers for use in human health and the environment. MetabolomeIDF is certified by IBiSA.Supervisor: Christophe JUNOT
Héliobiotec (at the CEA-IBEB in Cadarache) is a biotechnology platform set up to explore the potentials of microalgae (in the production of energy) and bio-sourced molecules (for green chemistry). The platform is equipped with high throughput screening systems, a cryobank of photosynthetic microorganisms, a collection of photobioreactors, and a variety of analytical equipment, particularly for lipidomics. Supervisor: Gilles PELTIER
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.