A 2-years position, funded by “Institut National du Cancer" (INCa) is available at the LREV lab/ INSERM U1274 / iRCM at CEA Paris-Saclay (Fontenay-aux-Roses site, 25 min from Paris) for a talented and highly motivated post-doc with a PhD in molecular biology, cell biology, genetics or a related field.
About the Team and Host institute
The LREV team is interested in understanding: 1) Genome maintenance mechanisms (DNA repair, senescence, telomere stability) in relation to the architecture of the nuclear envelope; 2) Biological responses to ionizing radiation (repair, oxidative stress, replicative stress, inflammation, immune cell death). Our projects aim to investigate the mechanisms involved in tumorigenesis related to the nuclear envelope, telomeres and DNA repair, as well as the response mechanisms to radiotherapy and to propose new therapeutic strategies. The LREV Team is part of the U1274/UMRE008 - Genetic Stability, Stem Cells and Radiation hosted by the iRCM/IBFJ/CEA in Fontenay-aux-Roses (25 min from Paris)
Project
The Post-doctoral project will focus on understanding how dysregulation of lamin B1, a major component of the nuclear envelope, can contribute to genomic instability and progression of tumorigenesis. Indeed, an alteration in the level of lamin B1 is observed in various cancers. The consequences of this alteration on chromosomal stability and tumorigenesis remain poorly understood. We have shown that lamin B1 overexpression triggers telomere instability by interfering with the shelterin, a protein complex that caps and safeguards telomeres. We recently discovered that lamin B1 directly interacts with the shelterin. We now aim to decipher the physiological roles of this interaction in different cellular models and analyze the consequences of its deregulation on cell fate in terms of genomic instability and tumor growth. This is a translational research program, from human primary culture and tumor cells derived from patients to tumor models, which combines cutting-edge cellular and molecular biology approaches such as molecular cytogenetics (FISH, multi-FISH), ChIP experiments, imaging, DNA-combing (SMARD).
Salary will be upon experience and according to Inserm's salary scales (from 2997 eur gross/ month). The postdoctoral position is expected to start in January 2025 (flexible)
Candidate Profile
We are looking for a talented and highly motivated post-doc with a solid experience in cellular and molecular biology to address these questions. The candidate must hold a PhD degree in molecular biology, cell biology, genetics and/or a related field. Strong expertise and skills in molecular biology, cellular biology, and cell cultures are required. Good knowledges in DNA repair, telomere, cancer research fields will be greatly appreciated. Language skills: very good level in English is expected.
Applicants should send their CV with a list of publications, names of references (2-3), a motivation letter describing interests and previous researches and
letter of recommendations of their previous institution(s) to Gaëlle Pennarun:
gaelle.pennarun@cea.fr
and Pascale Bertrand :
pascale.bertrand@cea.fr
Download the job offer :
Here
