Our institute is composed of 5 departments
Laboratories of the Institute
Publications, Books & Publishing, Defended theses
Studies carried out by scientists at IRIG, in collaboration with the University of Geneva, on the fruit fly model Drosophila melanogaster have revealed the role of Pcif1 in the control of gene expression, despite the fact that this protein has completely lost its RNA methyltransferase activity compared to its mammalian counterpart PCIF1. This study highlights an important contribution for Pcif1 in gene expression and physiology of the organism independently of any catalytic activity.
In living organisms, gene expression is a complex process that results in the production of proteins from the genome in a time- and space-regulated manner. This expression is strictly dependent on the synthesis of messenger RNAs transcripts from the DNA molecule and their subsequent translation into proteins by the ribosomes. As they are synthesized, mRNAs undergo chemical modifications that ensure their stability, their delivery to ribosomes and eventually their translation into proteins. These modifications include the addition of a cap at the 5' end and polyadenosines tail at the 3' end, as well as the addition of methyl groups on various nucleotides. These numerous modifications provide an additional level of information for the control of protein production and collectively form the epi-transcriptome.
Franco G, Taillebourg E, Delfino E, Homolka D, Gueguen N, Brasset E, Raman Pandey RR, Pillai RS and Fauvarque MOThe catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila. RNA 2023
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.