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Irradiation

​​UMR1274

Published on 27 September 2019
The aim of the Institute for Research in Cellular and Molecular Radiobiology (iRCM)  is to study the effect of ionizing radiations and their possible effects on the human health. 
Véronique MENARD
Principal Investigator
Phone: +33(0)1 46 54 99 29
veronique.menard@cea.fr

This institute have available an irradiation platform opened to labs which study the effect of ionizing radiations. 

This platform is open also to outside labs which need to irradiate their organic or non organic samples.


 

Technical Offer, Expertise and Commitment technique​

Technical Offer

  • Gamma irradiation with a self-shielded Cesium irradiator GRSD 1® from GSM company located at Fontenay-Aux-Roses.
  • XRAY cabinet located at Evry
  • Irradiation of whole organisms, in situ organ, tissue or cell cultures.
  • A secure and controlled environment (biosafety level 1 to 3).
  • X-ray cabinet called SARRP (Small Animals Radiation Research Platform) from XSTRAHL company located at Fontenay-Aux-Roses

Expertise 

  • Quality approach to manage the platform (safety control, dosimetrist daily and monthly check).
  • Physicist staff dedicated platform, project tracking (board).
  • Monitoring of the working of the platform.

​Commitment

  • Authorization of veterinary services of the prefecture.
  • Confidentiality of results.

​​Equipment

La plateforme d’irradiation de l’iRCM possède différents générateurs et irradiateurs qui sont situés sur le site de Fontenay-Aux-Roses et, sur le site d’Evry.

Located at Fontenay-Aux-Roses

  • Our GSDR1 is a self-shielded irradiator with four sources of  137Cesium













    GSRD 1®​
    ​. The total activity was around 180 TBq in March 2014 with a dose rate maximal of 14 Gy per min and minimal of 11 mGy. GSRD 1 is used to irradiate organic or non-organic materials.
  • Another GSRD 1 will be set up soon in order to provide irradiation but with a lower output than 11 mGy/min.






    Inside GSRD 1®

  • Un SARRP® pour Small Animals Radiation Research Platform de la société XSTRAHL.










SARRP®
​SARRP® (Small Animals Radiation Research Platform) from XSTRAHL company. It’s a X-ray generator combinated CBCT in order to mimic the human radiotherapy and perform targeted irradiation on a mouse.


Bioluminscence is available to use with SARRP in order to match BLI image and CBCT image to irradiate tumor less or no visible on CBCT.

SARRP can be used to irradiation cells but a specifical dosimetry has to be performed prior.


Variable aperture is available
to shape the beam as the form
and the size of the tumor

Sur le site d’Evry

  • A X-ray cabinet from PXI company with a maximal voltage of 350 kV.




 Results and Intellectual Property

In case the results would lead to a patent protection, condominiums results will be determined by the involvement of each partner and the terms of the previously established contract.

Additional Information

Users duties to the facility

  • Fill out the information sheet prior to irradiation (on request).
  • Establishment of a contract or a service provision agreement.
  • Signing and returning a previous estimate each benefit.