Actualité | Focus

A l'occasion de la journée mondiale d'Alzheimer, le 21 septembre 2018, découvrez quelques résultats montrant l’implication du CEA dans la recherche sur la maladie d’Alzheimer.

Scientific result

​A SB2SM Research Team (I2BC@Saclay) solved by crystallography the structure of a ternary protein complex at the interface between the nuclear envelope (emerin and lamin A / C) and the genome (BAF). In collaboration with Teams from Paris-Sud and Paris-Diderot Universities, the structure analysis, as well as in vitro interaction and proximity experiments in cellulo, suggests that a lack of interaction between the lamina A / C (nucleoskeleton) and chromatin-associated protein (BAF) may be one of the mechanisms responsible for premature aging syndromes.

Scientific result

SHFJ Researchers (IMIV), in collaboration with Vienna University, studied the brain transport of a drug, called metoclopramide. Radiolabelling of carbon-11 metoclopramide and PET imaging showed that a transporter of the blood-brain barrier, P-glycoprotein, blocked not only the entry of the drug into the brain but also facilitated the elimination to the blood. This result demonstrates for the first time in vivo and non-invasively a detoxification system able to eliminate certain compounds of the brain.