Vous êtes ici : Accueil > Départements et services > IDMIT > Séminaires internes

Séminaires internes

Publié le 25 juin 2018

​Le département IDMIT invite régulièrement des conférenciers exterieurs à présenter leurs travaux dans des séminaires.

A venir

  • Investigation of caveolin 1 structure and lipid-protein interactions in caveolae

    Laboratory

    ​Caveolin-1, a small membrane protein (21 KDa) plays a key role in the formation of caveolae defined from a morphological point of view as plasma membrane invaginations. These membrane structures are implicated in numerous cellular functions such as endocytosis, signalization, lipid transport and more recently mechanical stress. Our objective is to establish the molecular basis of the interactions networks associated with proteins and lipids in order to understand how the different networks of protein-lipid interactions are organized within these structures.

  • CEA-Leti and Davey Bickford Enaex Extend R&D Collaboration To Bring More Digital Solutions to Mining and Blasting Industries That Improve Safety for Workers and Increase Productivity

    Press release | News

    CEA-Leti and Davey Bickford Enaex, a worldwide leader in blasting solutions, have extended their joint laboratory for three years to continue development of innovative radio-frequency communication systems that remotely control networks of high-tech wireless electronic detonators.

  • Structure, fonction et régulation de protéines membranaires de transport associées à des pathologies

    Laboratoire

    La pertinence physiologique et thérapeutique des protéines de transport membranaire (MTP) se reflète dans le fait que les MTP représentent 15 % des cibles humaines approuvées par la FDA, et que 18 % de l'ensemble des médicaments approuvés par la FDA ciblent les MTP. Nous étudions les relations structure-fonction des transporteurs d'acides aminés liés à la maladie et des transporteurs codés par les parasites de la malaria. Notre objectif est de comprendre leur rôle biologique et leur physiopathologie, ainsi que de trouver de nouveaux mécanismes d'intervention pharmaceutique. À cette fin, nous combinons la biologie structurale, la spectroscopie et les outils biochimiques, y compris l'ingénierie des protéines.

  • Structure, function and regulation of disease-related membrane transport proteins

    Laboratory

    The physiological and therapeutical relevance of Membrane Transport Proteins (MTPs) is reflected by the fact that MTPs comprise ~ 15 % of the FDA-approved human targets, and that ~18 % of total FDA-approved drugs target MTPs. We study the structure-function relationships of disease-related amino acid transporters and transporters encoded by malaria parasites. Our goal is to understand their biological role and pathophysiology, as well as to find new mechanisms for pharmaceutical intervention. To this end we combine structural biology, spectroscopy and biochemical tools, including protein engineering.

  • Molecular mechanism of flippase-catalyzed transbilayer lipid transport

    Laboratory

    In our lab, we are interested in the molecular mechanism which underlies the transport of various molecules across membranes, and particularly in the transport of cations and lipids catalyzed by the P-type ATPase family. These transmembrane proteins play key roles in various cellular processes. We develop methods for the heterologous expression of membrane proteins in the yeast S. cerevisiae as well as for purification of these proteins (or protein complexes). We then combine biochemical, spectroscopy, and structural approaches for the functional characterization of target proteins.

Séminaires précédents