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Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
A nano-drug has been developed for treating certain neurological diseases such as brain ischemia, as well as injuries to bone marrow. It is composed of a therapeutic molecule, adenosine, and the vector squalene, which allows it to circulate in the body and reach the areas to be treated.
The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level.
A crossover study in neuroimaging and genetics has linked genetic mutations to variations in the size of deep brain structures. This is a new step in evaluating the risk factors for developing a neurodegenerative disease.
Formate dehydrogenases are bacterial enzymes that represent a hope in giving value to CO2 as a renewable energy vector. A team from the CEA-IBEB has elucidated a key step in their maturation.
Although they are involved in many biological mechanisms, disordered proteins have escaped the methods of structural biology. A team from the IBS has now succeeded in characterizing the interaction of two of them.
The collaboration between American laboratories and a team from the CEA-IRCM has shown in vitro that inhibitors of the enzyme ATR specifically kill the cells of certain types of cancer.
Notorious in its abnormal form, the normal prion protein is present in all mammals, although its role is unknown. A team from the CEA-IRCM has just shed some light on this.
Bisphenol A, now prohibited in food containers, is sometimes replaced by bisphenol S and bisphenol F. A team from the CEA-IRCM has now demonstrated that the latter are also potentially dangerous.
A team from the IBS has used solid-state NMR spectroscopy to obtain the structure of a key enzyme in the formation of the bacterial cell wall, revealing how it interacts with its substrate.
Stanislas Dehaene, professor at the Collège de France and a researcher at the CEA-I2BM, has won the “Lire” prize for the best book of the year in the science category, for “Le code de la conscience” (The Code of Consciousness).
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.