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Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Researchers at the Institut Pasteur, the CEA-IRTSV and the CNRS have shown that the direct environment of stem cells influences the fate of their offspring. According to the tension exerted on these cells types of in division, they can preferentially produce two new stem cells, or a stem cell and a specialized cell, or even two specialized cells.
Researchers from the CEA-IBITECS in collaboration with a team from the University of Strasbourg (UDS) have developed new reagents known as “chelating azides”, which can rapidly and selectively couple to any compound equipped with an alkyne group. The reaction can take place in any environment, including within a cell.
A team from the CEA-IBITECS participated in the identification of a novel role for an enzyme, the protease MMP-12, in the immune response to viral infection. The researchers developed an inhibitor of MMP-12, which enhances the immune response in a rodent model. This work, opens the way for the development of new antiviral therapies.
A French consortium, coordinated by INRA and involving the CEA (Genoscope), the CNRS and the Ecoles Normales Supérieures of Paris and Lyon, has sequenced and analyzed the genome of the rainbow trout . The result challenges a classic hypothesis in genetics.
DBV Technologies, creator of the Viaskin® patch for allergy treatment, has signed a collaborative agreement with the Centre National de Génotypage of the CEA-IG, to understand the epigenetic mechanisms of this treatment.
Non-coding regions of the genome appear to reduce the severity of two red blood cell diseases: beta thalassemias and sickle cell anemia. Researchers at the CEA-IRCM, in collaboration with English and Dutch laboratories, have elucidated mechanisms explaining how non-coding DNA sequences exert their action to improve symptoms of these two diseases.
A new type of giant virus, dubbed “Pithovirus”, was discovered in the frozen soil of extreme northeast Siberia by researchers from the CNRS/Aix-Marseille Université, CEA-IRTVS, CEA-IG and the Russian Academy of Sciences. Buried in the ground, this giant virus has survived more than 30,000 years of freezing.
A European consortium, of which the CEA-IMETI is a member, has developed a vaccine against the Chikungunya virus and tested it in a rodent model. Trials in humans could begin in 2015.
A study conducted by an international team, notably involving researchers from the CEA-IG (Genoscope), provides first-time evidence that measurable heritability may be based on epigenetic variations and not necessarily on variations in the DNA sequence.
The mass extinction of large animals during the last ice age is due to the climate, but what are the specific reasons for this? A collaboration involving 30 teams from 12 countries, including the CEA-IG, has provided some answers by sequencing free DNA taken from the Arctic permafrost.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.