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En 2010 et 2011, deux appels d’offre « Infrastructures Nationales en Biologie et Santé » ont été lancés dans le cadre du programme Biologie et Santé des Investissements d’Avenir (IA), soulignant l’importance des infrastructures technologiques de recherche pour maintenir une recherche d’excellence dans le domaine des sciences du vivant.
Actualités scientifiques du CEA de l'Institut de Biologie François Jacob.
Laboratory
The team's work focuses on the development of therapeutic molecules from research on bacterial and plant toxins.
Our research aims first to identify new toxins with original biological properties, secondly to characterize pharmacologically and structurally their interaction on their molecular targets, thirdly to change their functional properties by directed engineering and finally to exploit these ligands as tools to study these receptors and channels or as therapeutic agents. Furthermore, our work also aim to develop new detection systems of neurotoxic agents, based on their interaction with their molecular targets involved in nerve conduction and skeletal muscle contraction.
Function of zinc metalloproteases, approaches integrated from chemistry to in vivo: diagnostic and therapeutic applications.
Our team is working on the prediction and the mechanisms of the immunogenicity of therapeutic proteins and peptide vaccines in humans. Immunogenicity is the ability of molecules to induce an immune response. It is a major problem for the development of therapeutic proteins and a necessity for peptide vaccines.
Three main techniques are involved in the analysis facilities of SIMOPRO: Amino Acids Analysis, Edman Sequencing and Mass Spectrometry. They are used for both the quality control of all peptides and proteins production and for technically supporting SIMOPRO’s research projects.
CEA Paris-Saclay, Fontenay-aux-Roses
CEA Fontenay-aux-Roses, Building 52, Auditorium | Live broadcasting Faculté de Médecine de Bicêtre, room ED6
IDMIT/IMVA Scientific Seminar : Beta-Glucans and monocytes. We invite speakers, from France and from abroad, and who are experts in the fields of immunology, autoimmune diseases, infectious diseases, translational medicine, systems immunology, etc… to present and discuss their recent work.
Séminaire | Faculté de Médecine de Bicêtre, Room ED6 | Live broadcasting room 326 (3rd floor), building 62 (idmit), CEA, Fontenay-aux-Roses.
IDMIT/IMVA Scientific seminar : "Type I IFN regulation by natural and synthetic amines". We invite speakers, from France and from abroad, and who are experts in the fields of immunology, autoimmune diseases, infectious diseases, translational medicine, systems immunology, etc… to present and discuss their recent work.
Conférence | CEA Paris-Saclay, site de Fontenay-aux-Roses, Auditorium, Bâtiment 52
Le LIMS BATLab : un outil informatique évolutif au service des chercheurs et des plateformes technologiques. Cycle de Conférences IDMIT : présentation des technologies, équipements et savoir-faire dont peut bénéficier une large communauté de chercheurs.
Séminaire | CEA Fontenay-aux-Roses, Building 52, Auditorium | Live broadcasting Faculté de Médecine de Bicêtre, room ED6
IDMIT/IMVA Scientific Seminar : Microbiotas in digestive and respiratory health. We invite speakers, from France and from abroad, and who are experts in the fields of immunology, autoimmune diseases, infectious diseases, translational medicine, systems immunology, etc… to present and discuss their recent work.
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Acteur majeur de la recherche, du développement et de l'innovation, le CEA intervient dans quatre grands domaines : énergies bas carbone, défense et sécurité, technologies pour l’information et technologies pour la santé.