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PICCEL Publications and Patents

Publié le 11 mars 2026
  
Light-triggered quenching of the 19F-MRI signal from micelle-encapsulated PERFECTA.

​Leterrier C, Pinna G, Vandamme M, Glatigny M, Selingue E, Geffroy F, Mériaux S, Gravel E, Doris E.

2025
G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation

​Tricot S, Siberchicot C, Bontemps I, Desmaze C, Kratassiouk G, Vandamme M, Pinna G, Nemazanyy I, Radicella JP, Lenaers G, Renaudin X, Lebeau J, Campalans A

2025
Micelles based on a poly(2-oxazoline) triblock copolymer containing a pure stereoisomer E or Z-tetraphenylethylene core for theranostic applications.

Hoang S, Pinna G, Vandamme M, Allain M, Passirani C, Saulniera P, Krupka O.

2025
The LRP4/YAP axis drives the radiation-tolerant persister (RTP) cell state in breast cancer.

Forissier V, Wicinski J, Castagné M, Pinna G, Lin S, Grandon A, Bonnet C, Macario M, Castellano R, Valdenaire S, Darréon J, Tallet A, Ginestier C, Charafe-Jauffret E.

2025
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer.

Rouault CD, Bansard L, Martínez-Balsalobre E, Bonnet C, Wicinski J, Lin S, Colombeau L, Debieu S, Pinna G, Vandamme M, Machu M, Rosnet O, Chevrier V, Popovici C, Sobol H, Castellano R, Pasquier E, Guasch G, Rodriguez R, Pannequin J, Pascussi JM, Lachaud C, Charafe-Jauffret E, Ginestier C.

2025
Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors.

Kawai-Kawachi A, Lenormand MM, Astier C, Herbel N, Cutrona MB, Ngo C, Garrido M, Eychenne T, Dorvault N, Bordelet L, Song F, Bouyakoub R, Loktev A, Romo-Morales A, Henon C, Colmet-Daage L, Vibert J, Drac M, Brough R, Schwob E, Martella O, Pinna G, Shipley JM, Mittnacht S, Zimmermann A, Gulati A, Mir O, Le Cesne A, Faron M, Honoré C, Lord CJ, Chabanon RM, Postel-Vinay S.

2025
Tumor-Targeted Perfluorinated Micelles as Efficient Theranostic Agents Combining Positron Emission Tomography and Radiosensitization.

​Godel-Pastre S, Porcel E, Pinna G, Vandamme M, Denis C, Leterrier C, Doris E, Truillet C, Gravel E.

2024
Phototriggered Cytotoxicity of Ferrocene-Based Micelles - A Nonconventional Approach to Phototherapy.

​Hoang S, Vandamme M, Pinna G, Miserque F, Kučka J, Šefc L, Štěpánek P, Doris E, Hrubý M, Gravel E.

2024
Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms.

Ariey-Bonnet J, Berges R, Montero MP, Mouysset B, Piris P, Muller K, Pinna G, Failes TW, Arndt GM, Morando P, Baeza-Kallee N, Colin C, Chinot O, Braguer D, Morelli X, André N, Carré M, Tabouret E, Figarella-Branger D, Le Grand M, Pasquier E.

2023
OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression
Tanushi X, Pinna G, Vandamme M, Siberchicot C, D'Augustin O, Di Guilmi AM, Radicella JP, Castaing B, Smith R, Huet S, Leteurtre F, Campalans A.
2023
Genome-wide RNA interference screen in cancer stem cells.
Pinna G, Vandamme M, Rouault C, Charafe-Jauffret E, Ginestier C
2022
Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy.

​L'Hôte V, Courbeyrette R, Pinna G, Cintrat JC, Le Pavec G, Delaunay-Moisan A, Mann C, Thuret JY.

2021
Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity.

​Mbianda J, Bakail M, André C, Moal G, Perrin ME, Pinna G, Guerois R, Becher F, Legrand P, Traoré S, Douat C, Guichard G, Ochsenbein F.

2021
Tumor-targeted superfluorinated micellar probe for sensitive in vivo19F-MRI.

​Jamgotchian L, Vaillant S, Selingue E, Doerflinger A, Belime A, Vandamme M, Pinna G, Ling WL, Gravel E, Mériaux S, Doris E.

2021
The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway.

​Villa E, Paul R, Meynet O, Volturo S, Pinna G, Ricci JE.

2020
CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells.

​Rajabi F, Liu-Bordes WY, Pinskaya M, Dominika F, Kratassiouk G, Pinna G, Nanni S, Farsetti A, Gespach C, Londoño-Vallejo A, Groisman I.

2020
Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal.
Lebraud E, Pinna G, Siberchicot C, Depagne J, Busso D, Fantini D, Irbah L, Robeska E, Kratassiouk G, Ravanat JL, Epe B, Radicella JP, Campalans A
2020
MasterPATH: network analysis of functional genomics screening data
Rubanova N, Pinna G, Kropp J, Campalans A, Radicella JP, Polesskaya A, Harel-Bellan A, Morozova N.
2020
miRViz: a novel webserver application to visualize and interpret microRNA datasets.

​Giroux P, Bhajun R, Segard S, Picquenot C, Charavay C, Desquilles L, Pinna G, Ginestier C, Denis J, Cherradi N, Guyon L.

2020
Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization.

Bessonov N, Pinna G, Minarsky A, Harel-Bellan A, Morozova N.​​​

2019
Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level.

​Hoang MD, Vandamme M, Kratassiouk G, Pinna G, Gravel E, Doris E.

2019
Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.

Bakail M, Gaubert A, Andreani J, Moal G, Pinna G, Boyarchuk E, Gaillard MC, Courbeyrette R, Mann C, Thuret JY, Guichard B, Murciano B, Richet N, Poitou A, Frederic C, Le Du MH, Agez M, Roelants C, Gurard-Levin ZA, Almouzni G, Cherradi N, Guerois R, Ochsenbein F.

2019
A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells.

​Arfaoui A, Rioualen C, Azzoni V, Pinna G, Finetti P, Wicinski J, Josselin E, Macario M, Castellano R, Léonard-Stumpf C, Bal A, Gros A, Lossy S, Kharrat M, Collette Y, Bertucci F, Birnbaum D, Douik H, Bidaut G, Charafe-Jauffret E, Ginestier C.

2019
Glucocorticoids delay RAF-induced senescence promoted by EGR1.

​Carvalho C, L'Hôte V, Courbeyrette R, Kratassiouk G, Pinna G, Cintrat JC, Denby-Wilkes C, Derbois C, Olaso R, Deleuze JF, Mann C, Thuret JY.

2019
Biotin-functionalized targeted polydiacetylene micelles.

​Doerflinger A , Quang NN , Gravel E , Pinna G , Vandamme M , Ducongé F , Doris E .

2018
Incorporating interaction networks into the determination of functionally related hit genes in genomic experiments with Markov random fields.
Robinson S, Nevalainen J, Pinna G, Campalans A, Radicella JP, Guyon L.
2017
miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling.

​El Helou R, Pinna G, Cabaud O, Wicinski J, Bhajun R, Guyon L, Rioualen C, Finetti P, Gros A, Mari B, Barbry P, Bertucci F, Bidaut G, Harel-Bellan A, Birnbaum D, Charafe-Jauffret E, Ginestier C.

2017
IMP-3 protects the mRNAs of cyclins D1 and D3 from GW182/AGO2-dependent translational repression.

​Deforzh E, Vargas TR, Kropp J, Vandamme M, Pinna G, Polesskaya A.

2016
CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation.

​Galardi S, Petretich M, Pinna G, D'Amico S, Loreni F, Michienzi A, Groisman I, Ciafrè SA.​

2016
Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation.

Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C.

2016
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Patents
MICELLES IN CANCER TREATMENT​

Inventor(s): DORIS E, GRAVEL E, HOANG S, PINNA G, VANDAMME M, HRUBÝ M.

Patent Number(s): EP4434996A1;EP4688798A1;WO2024200314A1​

Patent Assignee: Commissariat Energie Atomique

The invention relates to the pharmaceutical field.In particular, the invention relates to the field of diagnosis and cancer treatment.Herein, the inventors provide biocompatible and photodegradable micelle compositions that can target and release iron on demand, causing ferroptosis in vivo, and more particularly in cancer cells, and tissues thereof.



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