PsD-DRT-12-0045
| Research Field | Chemistry
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| Domaine-S |
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| Theme | Condensed matter physics, chemistry & nanosciences
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| Theme-S |
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| Domaine | Chemistry
Condensed matter physics, chemistry & nanosciences
DRT
DTBS
SBSC
LFCM
Grenoble
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| Title | Immunotargeting of based-organic nanoparticles for clinical applications
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| Abstract | The project aims to tailor-make based-organic nanocarrier enabling to target antibodies to increase the efficacy of therapy (more particularly mantle cell lymphoma) for clinical applications. Our group has developed a unique delivery system based on lipid nanoparticles for imaging and therapeutic purposes since the last 6 years. Based on this technology, the candidate will:
- optimize the targeting of specific ligands into organic nanoparticles (bioconjugate chemistry)
- optimize the encapsulation of drugs in the immunotargeted nanoparticles
- assess the physico-chemical characterization of all nanoparticles
- evaluate the binding affinity of doped and targeted nanoparticles
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| Location | Département Microtechnologies pour la Biologie et la Santé (LETI)
Service Bio-System on Chip
Laboratoire Fonctionnalisation & Chimie pour les Microsystèmes
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| Pcontact | COUFFIN
Anne-Claude
CEA
DRT/DTBS/SBSC/LCMI
17, rue des Martyrs
38054 Grenoble cedex 09
04.38.78.03.25
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| Start date | 1/1/2012 |
| Contact person | anne-claude.couffin@cea.fr
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