Versatile and biocompatible lipid-based delivery system for bio-medical applications
What is Lipidot® technology?
Leti’s Lipidot® technology is a versatile nano-delivery platform to diagnose and provide medical treatments based on each patient’s characteristics. Lipidot® are small droplets of lipids that encapsulate, carry and deliver within the target cells / tissues: active drug compounds, imaging contrast agents and other lipophilic payload. These droplets also vectorize biomacromolecules – i.e nucleic acids, peptides, proteins, etc. Their composition, size, dosage forms and rheological properties can be tailored depending on the targeted site. More specifically, Lipidot® display target-specific affinity towards liver, lymph nodes, solid tumor, or lipid-rich areas such as atherosclerotic plaques. Lipidot® lipid droplets are composed of bioabsorbable and biocompatible ingredients, which are already FDA approved for human-use.
Applications
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Fluorescent dye transporter for in vitro & in vivo diagnostics and surgery guidance
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Drug transporter for chemotherapy and photodynamic therapy
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Nucleic acid delivery / SiRNA transfection agents for in vitro diagnostic and gene therapy
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Adjuvant delivery system for vaccines and immunotherapy
What's new?
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Lipid core for easy solubilization of lipophilic drugs
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Highly biocompatible and bioassimilable ingredients
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Versatile technology with a range of diameter (from 30 nm to 120 nm), dosage forms and rheological properties (fluid dispersions, viscous gels)
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High colloidal stability (> 18 months, 4°C to 40°C, 2<pH<10)
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Up-scalable solvent-free process
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Process validated at both lab-scale and industrial scale
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Pilot line capabilities and associated analytical characterization
What's next?
New applications under development
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PET imaging agents for atherosclerosis
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Preclinical validation at the late stage of siRNA delivery in vivo in a context of inflammatory bowel diseases (NewDeal project H2020)
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Challenge-test of a nanovaccine formulation in a model of infectious diseases in order to demonstrate an induction of protective immunity
- Currently under industrialization with V-NANO for up-scale and GMP production (up to 60L)