Vous êtes ici : Accueil > Départements et services > IRCM > UMR SGCSR > Publications du LSHL

Publications du LSHL

Publié le 27 juin 2018
  
Hypoxia favors chemoresistance in T-ALL through a HIF1-mediated mTORC1 inhibition loop
L Fahy, J Calvo, S Chabi, L Renou, C Le Maout, S Poglio, T Leblanc, A Petit, A Baruchel, P Ballerini, I Naguibneva, R Haddad, ML Arcangeli, F Mazurier, F Pflumio* and B Uzan
2021
Desperately seeking a home marrow niche for T-cell acute lymphoblastic leukaemia.
Calvo J, Fahy L, Uzan B, Pflumio F.
2019
Combined G-CSF and Plerixafor enhance hematopoietic recovery of CD34+ cells from poor mobilizer patients in NSG mice.
Arcangeli ML, Brault P, Bourhis JH, Kuhnowski F, Henry E, Barroca V et al.
2020
Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia.
Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho B-K et al.
2020
Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis.
Chabi S, Hong Van To T, Leavitt R, PhD4, Poglio S, Gonçalves Jorge P , Jaccard M, PeterssonK, Petit B, Roméo, PH, Pflumio,F, Vozenin, MC and Uzan, B
2020
Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations
Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefèvre, Vilma Barroca, Anna Campalans, Véronique Ménard, Julien Calvo, Françoise Pflumio, Marie-Laure Arcangeli
2020
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.
Roos-Weil D, Decaudin C, Armand M, Della-Valle V, Diop MK, Ghamlouch H, Ropars V, Hérate C, Lara D, Durot E, Haddad R, Mylonas E, Damm F, Pflumio F, Stoilova B, Metzner M, Elemento O, Dessen P, Camara-Clayette V, Cosset F-L, et al
2019
Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.
Labarthe L, Henriquez S, Lambotte O, Di Santo JP, Le Grand R, Pflumio F, Arcangeli M-L, Legrand N & Bourgeois C
2019
Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors.
Chabi S, Uzan B, Naguibneva I, Rucci J, Fahy L, Calvo J, Arcangeli M-L, Mazurier F, Pflumio F & Haddad R
2019
Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.
Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli M-L, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, et al
2019
T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7.
Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata J-T, Bastie J-N, Delva L, Pflumio F, Quéré R
2019
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL
Touzart A, Lengline E, Latiri M, Belhocine M, Smith C, Thomas X, Spicuglia S, Puthier D, Pflumio F, Leguay T, Graux C, Chalandon Y, Huguet F, Leprêtre S, Ifrah N, Dombret H, Macintyre E, Hunault-Berger M, Boissel N, Asnafi V.
2019
Saracatinib impairs maintenance of human T-ALL by targeting the LCK tyrosine kinase in cells displaying high level of lipid rafts.
Buffière A, Accogli T, Saint-Paul L, Lucchi G, Uzan B, Ballerini P, Bastie J-N, Delva L, Pflumio F, Quéré R
2018
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells
Karamitros D, Stoilova B, Aboukhalil Z, Hamey F, Reinisch A, Samitsch M, Quek L, Otto G, Repapi E, Doondeea J, Usukhbayar B, Calvo J, Taylor S, Goardon N, Six E, Pflumio F, Porcher C, Majeti R, Gottgens B, Vyas P
2018
Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia
Cahu X, Calvo J, Poglio S, Prade N, Colsch B, Arcangeli ML, Leblanc T, Petit A, Baleydier F, Baruchel A, Landman-Parker J, Junot C, Larghero J, Ballerini P, Delabesse E, Uzan B, Pflumio F
2017
Bone Marrow Hematons: An Access Point to the Human Hematopoietic Niche
Janel A, Berger J, Bourgne C, Lemal R, Boiret-Dupre N, Dubois-Galopin F, Dechelotte P, Bothorel C, Hermet E, Chabi S, Bay JO, Lambert C, Pereira B, Pflumio F, Haddad R, Berger MG
2017
ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia
Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mouel L, Thiollier C, Siret A, Dessen P, Aid Z, Riviere J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T
2017
Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia
Renou L, Boelle PY, Deswarte C, Spicuglia S, Benyoucef A, Calvo J, Uzan B, Belhocine M, Cieslak A, Landman-Parker J, Baruchel A, Asnafi V, Pflumio F, Ballerini P, Naguibneva I
2017
PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells
Naudin C, Hattabi A, Michelet F, Miri-Nezhad A, Benyoucef A, Pflumio F, Guillonneau F, Fichelson S, Vigon I, Dusanter-Fourt I, Lauret E
2017
Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage
Correia NC, Arcangeli ML, Pflumio F, Barata JT.
2016
Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.
Chesnais V, Arcangeli ML, Delette C, Rousseau A, Guermouche H, Lefevre C, Bondu S, Diop M, Cheok M, Chapuis N, Legros L, Raynaud S, Willems L, Bouscary D, Lauret E, Bernard OA, Kosmider O, Pflumio F, Fontenay M.
2016
DNMT3A mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice.
Scourzic L, Couronne L, Pedersen MT, Della Valle V, Diop M, Mylonas E, Calvo J, Mouly E, Lopez CK, Martin N, Fontenay M, Bender A, Guibert S, Dubreuil P, Dessen P, Droin N, Pflumio F, Weber M, Gaulard P, Helin K, Mercher T, Bernard OA.
2016
Speed of leukemia development and genetic diversity in xenograft models of T cell Acute Lymphoblastic Leukemia.
Poglio S, Lewandowski D, Calvo J, Caye A, Gros A, Laharanne E, Leblanc T, Landman-Parker J, Baruchel A, Soulier J, Ballerini P, Clappier E, Pflumio F.
2016
Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.
Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V.
2016
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hebert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M.
2016
Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-kappa B pathway activation but not with poor prognosis.
Poglio S, Cahu X, Uzan B, Besnard-Guerin C, Lapillonne H, Leblanc T, Baruchel A, Landman-Parker J, Petit A, Baleydier F, Amsellem S, Baud V, Ballerini P, Pflumio F.
2015
The SCL/TAL1 transcription factor represses the stress protein DDiT4/REDD1 in human hematopoietic stem/progenitor cells.
Benyoucef A, Calvo J, Renou L, Arcangeli ML, van den Heuvel A, Amsellem S, Mehrpour M, Larghero J, Soler E, Naguibneva I, Pflumio F.
2015
SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia
Pasmant E, Gilbert-Dussardier B, Petit A, de Laval B, Luscan A, Gruber A, Lapillonne H, Deswarte C, Goussard P, Laurendeau I, Uzan B, Pflumio F, Brizard F, Vabres P, Naguibvena I, Fasola S, Millot F, Porteu F, Vidaud D, Landman-Parker J, Ballerini P
2015
Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
Uzan B, Poglio S, Gerby B, Wu CL, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guerin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F.
2014
A Systems Biology Approach for Defining the Molecular Framework of the Hematopoietic Stem Cell Niche
Charbord P, Pouget C, Binder H, Dumont F, Stik G, Levy P, Allain F, Marchal C, Richter J, Uzan B, Pflumio F, Letourneur F, Wirth H, Dzierzak E, Traver D, Jaffredo T, Durand C
2014
1 - 30Suivante