Organoid-on-a-chip
Microfluidic devices with cellular systems that model human physiology and pathologies to facilitate targeted healthcare
What's new?
CEA-Leti's organoids-on-a-chip enable precise monitoring by using:
- Organoid vascularization (in collaboration with CEA-Irig)
- On-board sensors for real-time monitoring of organoid physiological functions
- Innovative microfluidic architectures to integrate complex biological protocols
- Heterogeneous thermoplastic/silicon integration
- Pre-industrial equipments, rapid prototyping and support for industrialization
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What's next?
CEA-Leti teams are taking advantage of their unique working environment
to achieve a variety of goals:
Combining vascularization and immuno-competence on microfluidic components (in collaboration with CEA-Irig) - Organ-on-a-chip functionality using dedicated sensors
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Monitoring with holographic imaging and associated interpretative algorithms
Developing complex microfluidic test benches to control and monitor organs-on-a-chip Manufacturing micro-fluidic components that can be industrialized and standardized
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Publication
Microfluidic device integrating a network of hyper-elastic valves for automated glucose stimulation and insulin secretion collection from a single pancreatic islet, C. Quintard, E. Tubbs, J-L. Achard, F. Navarro, X. Gidrol, Y. Fouillet. Biosens Bioelectron (2022) doi: 10.1016/j.bios.2022.113967
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