To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
Within the Institute, the "Funding Research and Technology Transfer" team is at your disposal to identify the scientists and the skills you need to set up a joint project, to define the terms of a collaboration contract or study.
Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
The team is also at the disposal of the researchers of the institute to accompany them in achieving their valorization objectives.
Brain | Neurodegenerative diseases
group of Julien Flament is working on a new MRI modality, called CEST for Chemical
Exchange Saturation Transfer, allowing in
vivo mapping of some brain metabolites with a good spatial resolution. In
the framework of a translational project funded by ANR (HDeNERGY project).
Thanks to the good spatial resolution of CEST imaging, mice brain were segmented in several regions of interest (top panel). For each structure, the variation of glutamate level was measured between a group of control mice and heterozygous mice (bottom left) and between control mice and homozygous mice (bottom right) for the gene coding the mutant huntingtin protein. Variation maps reveal stronger alterations in the homozygous group and also a major alteration of the corpus callosum in both groups.
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.