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Brain | Neurodegenerative diseases
group of Julien Flament is working on a new MRI modality, called CEST for Chemical
Exchange Saturation Transfer, allowing in
vivo mapping of some brain metabolites with a good spatial resolution. In
the framework of a translational project funded by ANR (HDeNERGY project).
Thanks to the good spatial resolution of CEST imaging, mice brain were segmented in several regions of interest (top panel). For each structure, the variation of glutamate level was measured between a group of control mice and heterozygous mice (bottom left) and between control mice and homozygous mice (bottom right) for the gene coding the mutant huntingtin protein. Variation maps reveal stronger alterations in the homozygous group and also a major alteration of the corpus callosum in both groups.
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.