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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Inspired by a metalloenzyme that reduces CO₂ to CO, researchers from I2BC designed two variants of an iron-porphyrin-based catalyst that differ only in the spatial arrangement of the reactive groups in the second coordination sphere. One of these configurations achieves remarkable catalytic performance.
A team from SIMoS, in collaboration with a team from I2BC, has validated a quantitative bacterial two-hybrid system that they developed for the high-throughput analysis of protein–protein interactions (PPIs). This approach enables the quantitative analysis of PPIs based on data suitable for training AI models.
Researchers from NeuroSpin have published the first functional magnetic resonance imaging (fMRI) scans acquired using NeuroSpin’s ISEULT 11.7 Tesla MRI scanner, while exploring the challenges of this ultra-high-field MRI modality.
Researchers from I2BC, the University of Leicester, IPBS, and ISS have resolved the structure and identified specific contacts mediating interactions within a complex consisting of the Ku70/Ku80 heterodimer, DNA, and the exonuclease domain of the WRN protein, whose dysfunction is responsible for a rare disease associated with a high risk of cancer.
Using complementary imaging methods, researchers from NeuroSpin and the Vision Institute show that the propagation of action potentials in the myelinated axons of rodent optic nerves does not trigger neurovascular coupling.
Researchers from SIMoS, in collaboration with the University of Montpellier, have designed a highly selective chemical probe targeting the active form of extracellular matrix metalloproteases, with the aim of enabling single-step multiplex profiling by mass spectrometry within complex proteomes.
A study, led by I2BC teams, combining enzymology and structural biology, and using RNA microhelices that mimic the acceptor arm of tRNAs, reveals that the two substrates of a cyclodipeptide synthase (CDPS) share a common interaction mode within the enzyme’s catalytic site.
A team from NeuroSpin and Robert Debré Hospital used EEG to monitor changes in theta oscillations in preterm and full-term infants. Using spectral analysis of the EEG, the researchers observed an increase in these periodic signals, accompanied by inter-individual variability in preterm infants, indicating greater vulnerability.
A study conducted by researchers at DMTS shows that hypoxia does not have the same metabolic consequences on brain organoids depending on whether they are derived from cells of a male or female donor.
Nœtica Pharma, a very young startup emerging from research conducted at CEA-Joliot, has announced receiving the "Orphan Drug" designation from the European Medicines Agency for its drug candidate BRT002.
Researchers from Avignon University and SPI have investigated the proteome of the bacterium Bacillus cereus grown under anoxic conditions in order to gain a better understanding of the role of the TSPO protein in the bacterium’s physiology. They demonstrate that TSPO is a key regulator of porphyrin and iron metabolism, helping to maintain the environmental resilience of B. cereus.
Researchers from BioMaps, NeuroSpin and the Paris Psychiatry & Neurosciences University Hospital Group have unveiled the results of a two-year longitudinal study highlighting differences in white matter bundle alterations between patients with Alzheimer’s disease and those with LATE amnesia.
Researchers from DMTS designed bifunctional PROTAC chemical probes to identify the molecular target(s) of Retro-2 compounds, broad-spectrum inhibitors of intracellular pathogens. Although this approach did not identify new Retro-2 targets, it revealed a molecular glue effect involving the protein GSPT1.
A team from the SPI (DMTS) investigated the effects of hypoxia on the interface between the choroid plexus and cerebrospinal fluid using organoids derived from human pluripotent stem cells. The aim was to investigate how cerebral hypoxia at birth, which causes hypoxic-ischaemic encephalopathy, disrupts this cerebral barrier, which has not yet been extensively studied.
The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity.
In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts.
September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.