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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A team from SHFJ has developed an original method of 3D spirometry using pulmonary magnetic resonance imaging in a cohort of volunteers breathing freely. This approach has revealed the existence of common patterns among individuals that depend mainly on gravity. This is a step towards a regional pathophysiological characterisation of respiratory diseases.
Des chercheurs de BioMaps (SHFJ) et de MOODS ont validé une approche innovante de neuroimagerie moléculaire permettant de suivre, de manière non-invasive, les effets de la kétamine sur la densité synaptique dans un modèle préclinique de dépression.
A team of researchers from BioMaps (SHFJ) is proposing a new reconstruction method for PET imaging that combines optimization algorithms with deep neural networks. Their “plug-and-play” regularization approach ensures improved image quality thanks to PET-specific reconstruction learning, while guaranteeing stability and robustness—two critical aspects in the use of AI-based medical techniques.
Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged.
Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring.
Researchers from CEA-Jacob and the Genome Integrity team at I2BC, in collaboration with Gustave Roussy and the Institut Pasteur, demonstrate that the Rap1 protein prevents the translocation of the Ku protein— a major factor in double-strand break repair — thereby avoiding deleterious fusions between chromosomes.
Des chercheurs du SCBM en collaboration avec le SHFJ décrivent un nouveau paradigme pour le marquage isotopique au carbone de composés nitriles : plus simple, plus propre et universel, ouvrant la voie à une production élargie de molécules marquées d’intérêt en santé et en agrochimie.
A LI-MS team presents an innovative strategy and software for structural elucidation in metabolomics using tandem mass spectrometry.
Une équipe du LI-MS (SPI/DMTS) combine un protocole robuste d’immunoprécipitation de l’alpha-synucléine à de la spectrométrie de masse haute résolution et caractérise des formes tronquées inédites de la protéine.
Researchers from IRAMIS and SPI (DMTS) evaluated their GMR-sensor biochip prototype for its ability to detect cancer cells in a complex medium. This approach, which combines sensor physics with medical biology, aims to develop simpler and portable diagnostic tools that meet the WHO criteria for point-of-care testing.
Une étude menée par une équipe de l'I2BC montre que la surexcitation du photosystème II est responsable de la faible valeur de qL, un paramètre de fluorescence, chez des mutants d’Arabidopsis thaliana incapables de réaliser des « transitions d’état ».
Researchers from SIMoS (DMTS) contributed to the characterization of a nanobody (VHH) designed by scientists at the Institut de Génomique Fonctionnelle in Montpellier. They performed tritium labeling and biodistribution tracking of this VHH, which can specifically activate a glutamate receptor involved in schizophrenia. This work was published in Nature.
Researchers at SPI (DMTS) have developed a high-yield strategy for producing monoclonal antibodies by preselecting the antibody-producing cells most likely to form viable hybridomas. This represents a step towards a wider use of this technology which should help to further reduce the number of animals to be immunised.
Scientists at the EPFL, in collaboration with a team from SCBM (DMTS), have developed a new technique that enables, with unprecedented sensitivity, the measurement of circularly polarized light emitted by luminescent materials over time. This work has been published in Nature.
The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity.
In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts.
September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.