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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Nanobodies, promising biotherapeutic agents, may trigger undesirable immune reactions. A team from SIMoS demonstrates, using a sensitive assay on human T lymphocytes, that this risk exists for certain nanobodies and can be reduced through sequence humanization. These findings highlight the importance of assessing immunogenicity alongside therapeutic efficacy.
Researchers from the MIND team (NeuroSpin) and the Neuroscience Center in Helsinki describe a machine learning model that simplifies the interpretation of stereo-electroencephalography (SEEG) data acquired during the presurgical evaluation of drug-resistant epilepsy. This approach improves and facilitates the localization of the epileptogenic network.
Peptides and proteins adsorb onto plastic nanoparticles, forming a corona. Researchers from I2BC and CEA-Iramis, using molecular modeling, reveal distinct adsorption behaviors depending on their amino acid sequences. They thus establish a mechanical basis for predicting peptide-plastic interactions, a crucial element for assessing the risks these interactions pose to health and ecosystems.
Researchers from the I2BC show that two Arabidopsis thaliana mutants deficient in manganese transport do not regulate photosynthetic electron transport in the same way, with different consequences for photosynthesis.
Researchers from our DMTS department have published a study providing the first proof of concept for a CAR-macrophage therapy targeting the endothelin B receptor, which is overexpressed in melanoma cells.
Researchers from the DMTS have developed a method for exploring the chemical exposome in large, complex mass spectrometry datasets. They applied it to the analysis of meconium samples from a cohort.
A team from NeuroSpin investigated the impact of contrasting auditory environments on the morphology of the superior temporal sulcus (STS) in preterm newborns. By showing that exposure to music is associated with a deeper STS, the authors suggest that early auditory experience influences the structural development of temporal brain regions.
A team from NeuroSpin sheds light on the mechanisms underlying artifacts caused by intra-voxel dephasing, which occur when using ultra-high-field MRI acceleration methods such as GRAPPA.
Researchers from BAOBAB (NeuroSpin) have demonstrated that cortical folding is indeed a biomarker of brain development and that its genetic influences can be detected using deep learning methods.
A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.