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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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A study conducted by researchers at DMTS shows that hypoxia does not have the same metabolic consequences on brain organoids depending on whether they are derived from cells of a male or female donor.
A team from SIMoS, in collaboration with a team from I2BC, has validated a quantitative bacterial two-hybrid system that they developed for the high-throughput analysis of protein–protein interactions (PPIs). This approach enables the quantitative analysis of PPIs based on data suitable for training AI models.
Researchers from NeuroSpin have published the first functional magnetic resonance imaging (fMRI) scans acquired using NeuroSpin’s ISEULT 11.7 Tesla MRI scanner, while exploring the challenges of this ultra-high-field MRI modality.
Researchers from I2BC, the University of Leicester, IPBS, and ISS have resolved the structure and identified specific contacts mediating interactions within a complex consisting of the Ku70/Ku80 heterodimer, DNA, and the exonuclease domain of the WRN protein, whose dysfunction is responsible for a rare disease associated with a high risk of cancer.
Using complementary imaging methods, researchers from NeuroSpin and the Vision Institute show that the propagation of action potentials in the myelinated axons of rodent optic nerves does not trigger neurovascular coupling.
Researchers from SIMoS, in collaboration with the University of Montpellier, have designed a highly selective chemical probe targeting the active form of extracellular matrix metalloproteases, with the aim of enabling single-step multiplex profiling by mass spectrometry within complex proteomes.
A study, led by I2BC teams, combining enzymology and structural biology, and using RNA microhelices that mimic the acceptor arm of tRNAs, reveals that the two substrates of a cyclodipeptide synthase (CDPS) share a common interaction mode within the enzyme’s catalytic site.
A team from I2BC used ultrafast stimulated Raman spectroscopy under resonance conditions enabling the selective observation of vibrational contributions from the various excited states following photon absorption and reveal the vibrational signatures of three optically dark excited states in carotenoids.
Using high-resolution electroencephalography, a team from NeuroSpin has identified a significant link between the power of beta brain waves and hyper- and hypo-sensory particularities in autistic individuals aged between 5 and 17.
An I2BC team has studied, using both in vitro and in silico approaches, the dynamics of phosphatidylserine transport between the endoplasmic reticulum and the plasma membrane in the yeast S. cerevisiae. Their study reveals that the protein Ist2 exhibits lipid scramblase activity and identifies a functional partnership between Ist2 and the lipid transfer protein Osh6.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.