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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Researchers from I2BC, the University of Leicester, IPBS, and ISS have resolved the structure and identified specific contacts mediating interactions within a complex consisting of the Ku70/Ku80 heterodimer, DNA, and the exonuclease domain of the WRN protein, whose dysfunction is responsible for a rare disease associated with a high risk of cancer.
A team from I2BC used ultrafast stimulated Raman spectroscopy under resonance conditions enabling the selective observation of vibrational contributions from the various excited states following photon absorption and reveal the vibrational signatures of three optically dark excited states in carotenoids.
Using high-resolution electroencephalography, a team from NeuroSpin has identified a significant link between the power of beta brain waves and hyper- and hypo-sensory particularities in autistic individuals aged between 5 and 17.
An I2BC team has studied, using both in vitro and in silico approaches, the dynamics of phosphatidylserine transport between the endoplasmic reticulum and the plasma membrane in the yeast S. cerevisiae. Their study reveals that the protein Ist2 exhibits lipid scramblase activity and identifies a functional partnership between Ist2 and the lipid transfer protein Osh6.
Researchers from Avignon University and SPI have investigated the proteome of the bacterium Bacillus cereus grown under anoxic conditions in order to gain a better understanding of the role of the TSPO protein in the bacterium’s physiology. They demonstrate that TSPO is a key regulator of porphyrin and iron metabolism, helping to maintain the environmental resilience of B. cereus.
Researchers from BioMaps, NeuroSpin and the Paris Psychiatry & Neurosciences University Hospital Group have unveiled the results of a two-year longitudinal study highlighting differences in white matter bundle alterations between patients with Alzheimer’s disease and those with LATE amnesia.
Researchers from DMTS designed bifunctional PROTAC chemical probes to identify the molecular target(s) of Retro-2 compounds, broad-spectrum inhibitors of intracellular pathogens. Although this approach did not identify new Retro-2 targets, it revealed a molecular glue effect involving the protein GSPT1.
A team from NeuroSpin measured brain connectivity patterns using functional MRI data from a deep-phenotyping dataset involving several tasks (watching movies, listening to stories). The authors showed that sparse partial correlation is more effective for identifying individuals, whereas standard correlation performs better for distinguishing and classifying different cognitive tasks
A team from NeuroSpin designed an original learning paradigm to identify the brain code representing the probability of an event occurring. Results obtained using ultra-high-field functional MRI show that fronto-parietal regions encode this probability and that its representation relies on a highly non-monotonic code.
A team from the SPI (DMTS) investigated the effects of hypoxia on the interface between the choroid plexus and cerebrospinal fluid using organoids derived from human pluripotent stem cells. The aim was to investigate how cerebral hypoxia at birth, which causes hypoxic-ischaemic encephalopathy, disrupts this cerebral barrier, which has not yet been extensively studied.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.