To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs.
Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health.
Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines
NeuroSpin researchers show that spontaneous neuronal oscillations in the 'delta' frequency band (0.5-3 Hz), the wave of unconscious states, can be observed in awake human volunteers using MEG. A step towards characterizing underlying physiological signals?
Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation.
A team from SIMoS and SCBM, in collaboration with researchers from I2BC, has shown that autophagic degradation is at work when mammalian cells are poisoned by ricin. Stimulating this process could provide additional protection against this deadly toxin.
A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum
Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody.
The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy.
A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.