To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
Within the Institute, the "Funding Research and Technology Transfer" team is at your disposal to identify the scientists and the skills you need to set up a joint project, to define the terms of a collaboration contract or study.
Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
The team is also at the disposal of the researchers of the institute to accompany them in achieving their valorization objectives.
Researchers at NeuroSpin have developed a deconvolution method to estimate from BOLD fMRI data the coupling between neuronal activity and blood flow, the characteristic signals of neuronal activity and the associated brain areas. The work was published in NeuroImage.
Researchers at UNICOG (NeuroSpin) show, using a high-resolution electroencephalographic system, that speech, an extremely complex and variable acoustic signal, is perceived by infants as a sequence of stable and invariant segments through an encoding based on distinctive and orthogonal phonetic features, such as manner and place of articulation, which are secondarily combined into phonemes, such as ″b″ or ″m″.
By solving the three-dimensional structure of a fragment of the BRCA2-HSF2BP complex, a collaboration involving teams from I2BC and ERASMUS MC identifies the precise BRCA2 motif that causes the very high affinity between the two partners and shows that, in vivo, this complex has no function in the recruitment of Rad51 to meiotic sites of homologous recombination.
Researchers from I2BC (CEA-Joliot/CNRS/UPSay, in collaboration with the JP Bourgin Institute and the University of Vilnius, decipher for the first time the energy dissipation process called "singlet fission" in two natural flower carotenoids, a fundamental mechanism for the design of new and more efficient multi-electron photocatalysts.
Researchers at NeuroSpin (CEA-Joliot) propose to automate the classification and recognition of folding patterns on the surface of the cortex that may be related to the occurrence of psychiatric diseases or cognitive disorders using artificial intelligence algorithms. A path towards deciphering the "lines" of the brain.
In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets.
In a study published in JBC, a team from I2BC/CEA-Joliot, in collaboration with the Beijing Botanical Institute (China), describes for the first time an intermediate state of the light-harvesting antenna of higher plants that provides a better understanding of the changes that take place at the molecular level during the activation of a plant's photoprotection mechanism.
A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress.
A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA.
Researchers at I2BC/CEA-Joliot, in collaboration with the RPBS platform, have developed the third version of their InterEvDock server for structural modelling of protein-protein interactions. The server integrates new algorithms for exploiting sequence evolution information.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.