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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Researchers from BAOBAB (NeuroSpin) have demonstrated that cortical folding is indeed a biomarker of brain development and that its genetic influences can be detected using deep learning methods.
A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles.
Researchers from the BioMaps laboratory (SHFJ) demonstrate the value of artificial intelligence software in interpreting MRI data for monitoring individuals with multiple sclerosis. However, validation by clinical radiologists remains essential to ensure the accuracy of the interpretation.
DMTS teams have characterised 17 monoclonal antibody-candidates targeting ricin using two original biophysical approaches. The identification of ricin residues involved in functional antibody recognition paves the way for the development of powerful monoclonal therapeutic antibodies against this natural toxin, which is a bioterrorism agent.
A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies.
Teams from BioMaps (SHFJ) and BAOBAB (NeuroSpin), along with CEA-Jacob, are optimizing their strategy for opening the blood-brain barrier (BBB) using focused ultrasound (FUS) to deliver drugs to the brain. Their innovation: an algorithm that identifies and 'eclipses' extracranial cavitation induced by thick temporal muscles—particularly in large male primates—which otherwise masks the signal of interest.
A team from SHFJ has developed an original method of 3D spirometry using pulmonary magnetic resonance imaging in a cohort of volunteers breathing freely. This approach has revealed the existence of common patterns among individuals that depend mainly on gravity. This is a step towards a regional pathophysiological characterisation of respiratory diseases.
Researchers from BioMaps (SHFJ) and MOODS have validated an innovative molecular neuroimaging approach that allows non-invasive monitoring of ketamine’s effects on synaptic density in a preclinical model of depression.
A team of researchers from BioMaps (SHFJ) is proposing a new reconstruction method for PET imaging that combines optimization algorithms with deep neural networks. Their “plug-and-play” regularization approach ensures improved image quality thanks to PET-specific reconstruction learning, while guaranteeing stability and robustness—two critical aspects in the use of AI-based medical techniques.
Researchers at the SCBM and BAOBAB have developed a new version of their nanometric micellar vector designed for fluorine-19 magnetic resonance tumor imaging. This version is intended to enhance MRI contrast by switching off the signal on demand in certain areas, while preserving it in pathological regions to be imaged.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.