To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
Within the Institute, the "Funding Research and Technology Transfer" team is at your disposal to identify the scientists and the skills you need to set up a joint project, to define the terms of a collaboration contract or study.
Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
The team is also at the disposal of the researchers of the institute to accompany them in achieving their valorization objectives.
Researchers at the "Laboratoire Innovations technologiques pour la Détection et le Diagnostic" (LI2D, in Marcoule) of the Department of Medicines and Technologies for Health (DMTS) have developed a mathematical method to identify in a metaproteomics dataset the contribution of each of the organisms that make up a microbiota. This robust method, called phylopeptidomics, is described in the journal Microbiome.
A study conducted by a multidisciplinary team from NeuroSpin, in collaboration with researchers from the AP-HP (Hôpitaux Universitaires St Louis-Lariboisière-F Widal), reveals for the first time, by 7Tesla MRI of Lithium-7, an accumulation of Lithium in the left hippocampus of patients with bipolar disorder and treated with Lithium. These results should help to better understand the therapeutic response to this drug.
Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit.
Researchers from SIMoS, SCBM and Institut Curie, in collaboration with Carnegie Mellon University (USA), have identified the intracellular target and the mechanism of action of Retro-2, a broad-spectrum inhibitor of intracellular toxins and pathogens. They are now working on the design of an effective drug in the event of a bioterrorist attack or a health crisis.
Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans.
Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18.
A team from NeuroSpin, in collaboration with researchers from the Sainte-Anne Hospital and from the University of Minho, has developed, using magnetic resonance imaging, a unique set of resources for the analysis and visualization of preclinical data in the rat brain.
NeuroSpin researchers have developed a software for preprocessing non-human primate brain raw images obtained by functional magnetic resonance imaging. The aim is to help harmonize methods, improve procedures, facilitate comparison and interpretation of the acquired images and to minimize the number of animals to be used in research.
Researchers from IRAMIS collaborated with a team from SPI (LERI) for the development of a microfluidic biochip ("lab-on-chip") based on ultra-sensitive magnetic sensors with giant magnetoresistance (GMR sensors), capable of individually and effectively detect magnetically-labeled biological targets.
A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery".
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.