To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Conference | Brain
From 6/12/2023 to 6/12/2023
Jean-Pierre MOTHET (Université Paris-Saclay, LuMIn Lumière Matière et Interfaces) has given a talk.
The last two decades have witnessed remarkable advances in our understanding of the role of right-handed (D-) amino acids in Mammals and particularly in the nervous system: from the unknown, to known molecules with unknown functions, to key players in health and disease. D-Amino acids have emerged as an important class of neuromodulators. In particular, the exploration of the roles of D-serine in brain physiopathology is a vibrant field that has flourished at an accelerating pace. During my talk I will show how our discovery that D-serine is regulating NMDA receptors has dramatically transformed our vision of the mechanisms regulating excitatory neural circuitries and brain functioning and is now offering therapeutical promise for treating some of the major neuropathologies. I will also introduce new data from our lab that extends the physiological landscape of D-serine in circuits physiology but will also highlight the unmet frontiers in system and clinical neuroscience to be next reached.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.