To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Europe | Diagnosis and innovative treatment
Worldwide every year, 1.2 million people die of severe end-stage chronic liver disease (decompensated cirrhosis and acute or chronic liver failure). The main causes of the disease are alcoholism and viral infections (hepatitis), some factors such as diabetes and obesity aggravating the prognosis. Among recent advances in understanding the disease, the role of the intestinal microbiota1 (formerly known as intestinal flora) in the pathogenesis and evolution of the disease is of great interest. Quantitative and qualitative differences in its composition exist between cirrhotic and healthy people. There are related to the migration of certain microorganisms from or to other microbiota of the body (salivary, circulatory microbiota ...). The study of the microbiota, or rather the microbiome2, must therefore make it possible, on the one hand, to predict and prevent the occurrence and/or aggravation of cirrhosis and, on the other hand, to propose appropriate therapeutic solutions and custom.
 A microbiota is all the microorganisms (baceria, viruses, fungi, archae) that are present in a specific environment. Human body hosts several microbiota (cutaneous, circulatory, salivary, vaginal...).
 Initialy, microbiome describes the collective genomes of the microorganisms from a microbiota. With omics technologies, microbiome encompasses today transcriptome, proteome, and metabolome from a single microbiota.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.