To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Scientific result | Cognition | MRI | Diseases
As part of the InFoR-Autism scientific program involving NeuroSpin, a new neuroimaging study has revealed a correlation between decreased local anatomical connectivity and social cognitive deficits in people with autism spectrum disorders (ASD). Published in the renowned journal Brain, the results challenge the dominant theoretical model explaining ASD and could pave the way for the exploration of new therapeutic approaches. The researchers used critical high-resolution neuroimaging data for the analysis that were obtained as part of the creation of the HBP Brain atlas.
Autism Spectrum Disorders (ASDs) are caused by developmental disruptions characterized by communication disorders, altered social interactions and sensory and behavioural abnormalities. Research in genetics and brain imaging suggests that alterations in brain development, including the formation of neural networks and the functioning of synapses, may contribute to the development of ASDs.
In recent years, neuroimaging studies have shown that people with ASDs have abnormalities in the functioning of certain brain areas known to be responsible for processing emotions, language or social skills. Research on the brain connectivity of people with ASD has shown in particular a lack of "long distance" connections in contrast to an increase in "short distance" connectivity. These results formed the basis for the development of a theoretical model for understanding ASDs, according to which the lack of social attention and information processing (difficulty in understanding a situation as a whole, attention to detail) is explained by an oversaturation of information processed within the brain, linked to the increase in neural connectivity between adjacent brain areas.
However, Professor Josselin Houenou, Professor of Psychiatry at the UPEC, Inserm U955, a practitioner at the Henri Mondor University Hospitals and a researcher at NeuroSpin, points out: "this model is based on the study of heterogeneous paediatric populations, including autistic children of variable ages and very varied symptomatology, and on non-specific neuroimaging methods that do not allow reliable measurement of connectivity"'short distance". »
At this point, an innovation from the Human Brain Project (HBP) provided a way to test the current model. Within the HBP, scientists throughout Europe collaborate to integrate vast amounts of neuroscientific data into the most comprehensive model of the brain to date as a resource that is open to scientists and clinicians worldwide. Neurospin is one of the central partner institutions in this endeavor. As part of the work scientists Miguel Guevara, Jean-François Mangin and Cyril Poupon from NeuroSpin had created an atlas specifically dedicated to the tractography of 63 "short distance" connections from images obtained by diffusion MRI (dMRI). This method allows highlighting the white matter fibres of the brain in vivo by measuring the diffusion of water molecules, especially along axons. It is then possible by tractography to reconstruct the paths of the nerve fibre bundles represented in the form of a tractogram.
3D visualization of the atlas of "short distance" fibre connections used to compare subjects with Autism spectrum disorder to control subjects. The colours in the figure correspond either to a fibre bundle or to one of the cortical folds bypassed by the fibre bundles. © M. Guevara, C. Poupon, JF. Mangin / CEA
The authors were thus able to study the links between "short distance" connectivity and social cognition in a homogeneous adult population of people with ASD from the InFoR-Autism* cohort (27 persons with ASD without intellectual disabilities and 31 control persons). "The power of the InFoR-Autism* cohort lies in the great richness of the data collected for each subject included. We were thus able to link the neuroimaging results obtained with social cognition scores, measuring social ability, empathy, social motivation, etc.," recalls Dr Marc-Antoine d'Albis (HU Henri Mondor, Inserm U955), first author of the study and also a researcher at NeuroSpin.
The results obtained show that subjects with ASD have a decrease in connectivity in 13 "short distance" fibre bundles compared to control subjects. In addition, this anomaly in the connectivity of "short distance" connections is correlated with a two-dimensional deficit in social cognition (social interactions and empathy) in subjects with ASD). These preliminary results are in stark contrast to the current theoretical model that the lack of social attention and information processing in people with ASDs is due to an increase in neural connectivity between adjacent brain areas. They now need to be confirmed by studies conducted in children with ASDs, as explained by Professor Josselin Houenou.
Translation of the original text published on the French Frédéric Joliot Institute's website adapted with permission from: https://www.humanbrainproject.eu/en/follow-hbp/news/understanding-autism-novel-brain-imaging-study-challenges-the-dominant-explanation/
Local structural connectivity is associated with social cognition in Autism Spectrum Disorder. MA d'Albis, P Guevara, M Guevara, C Laidi, J Boisgontier, S Sarrazin, D Duclap, R Delorme, F Bolognani, C Czech, C Bouquet, M Ly-Le Moal,
S Holiga, A Amestoy, I Scheid, A Gaman, M Leboyer, C Poupon, JF Mangin, J Houenou. | 2018 Brain
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.