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Scientific result | Chemistry
A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D2 or T2 as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterated oligonucleotides suitable for use as internal standards during LC‐MS quantification.
A. Palazzolo, S. Feuillastre, V. Pfeifer, S. Garcia-Argote, D. Bouzouita, S. tricard, C. Chollet, E. Marcon, D.A. Buisson, S. Cholet, F. Fenaille, G. Lippens, B. Chaudret, G. Pieters. Efficient access to deuterated and tritiated nucleobase pharmaceuticals and oligonucleotides using hydrogen isotope exchange. | Angewandte Chemie, 2019.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.