To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Scientific result | Health ＆ life sciences | Brain | Alzheimer's disease
Researchers from SEPIA1 (François Jacob Institute of Biology) and CellTechs (Sup'Biotech engineering school), working in partnership with LEMM2 (Frédéric Joliot Institute for Life Sciences), all within or affiliated with the CEA, have developed a new approach for modeling Alzheimer's disease in vitro using human induced pluripotent stem cells (iPSCs). Their work builds upon the ability of iPSCs to differentiate into "mini-brains", that is, three-dimensional cellular structures recapitulating human brain development.
Four mini-brains in a Petri dish.© CellTechs/Sup’Biotech
5X microscopic view of a 20-day-old « mini-brain ».© CellTechs/Sup’Biotech
Immunohistochemical analysis of a mini-brain. (1) Antibody labelling of vimentin (an intermediate filament protein present in astrocytes) (2) Antibody labelling of Tuj-1 (neuron specific), 40X magnification.© CellTechs/Sup’Biotech
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.